Juliusson G, Friberg K, Gahrton G
Department of Medicine, Huddinge Hospital, Stockholm, Sweden.
Acta Oncol. 1988;27(5):473-7. doi: 10.3109/02841868809093573.
Chromosome analyses of B-cell mitogen-activated cells from 95 patients with chronic B-lymphocytic leukaemia revealed clonal chromosomal aberrations in 50 patients (53%), of which 24 had an extra chromosome 12 with or without other aberrations. Patients with clonal aberrations, especially those with +12, had poorer survival than other patients. Longitudinal studies, with a mean of 3.5 samplings during a median interval of 3.5 years, were performed in 41 patients, of which 24 (59%) had progressive disease. Twenty-nine of the patients in the longitudinal study (71%), 16 with and 13 without clonal aberrations, retained their karyotype unaltered. In 6 patients a clonal aberration was found only once. Six patients showed minor changes of the karyotype. The karyotype seems to be established at diagnosis, and marks the disease of the individual CLL-patient.
对95例慢性B淋巴细胞白血病患者的B细胞有丝分裂原激活细胞进行染色体分析，发现50例患者（53%）存在克隆性染色体畸变，其中24例有额外的12号染色体，伴或不伴有其他畸变。有克隆性畸变的患者，尤其是有+12的患者，其生存期比其他患者短。对41例患者进行了纵向研究，平均在3.5年的中位间隔内进行了3.5次采样，其中24例（59%）有疾病进展。纵向研究中的29例患者（71%），16例有克隆性畸变，13例无克隆性畸变，其核型保持不变。6例患者仅发现一次克隆性畸变。6例患者核型有微小变化。核型似乎在诊断时就已确立，并标志着个体慢性淋巴细胞白血病患者的病情。
