Yuan Guangda, Zhan Cheng, Zhu Donglin, Xie Hongya, Wei Tengteng, Lu Tao, Yang Yong, Zhu Yimeng, Wang Qun
Department of Thoracic Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, China.
Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
J Thorac Dis. 2019 Dec;11(12):5480-5488. doi: 10.21037/jtd.2019.11.34.
Esophageal large cell neuroendocrine carcinoma (ELCNC) seems a rarely gastrointestinal malignancy. By far, its clinicopathological characteristics and prognosis have not been deeply studied.
The data of patients having ELCNC was extracted from the Surveillance, Epidemiology, and End Results (SEER) database, then assessed and compared with information from patients with esophageal small cell neuroendocrine carcinoma (ESCNC) or esophageal squamous cell carcinoma (ESCC). We used univariate and multivariate analyses to accurately detect independent prognostic factors.
The data of 36 patients for ELCNC were obtained between 2004 and 2015. Compared with patients with ESCNC and ESCC, the mean survival time of ECLNC patients was worse than those with ESCC, while similar to ESCNC. Thus, ELCNC had significantly different clinicopathological characteristics compared to ESCNC and ESCC. Univariate and multivariate analyses revealed that age (P=0.001) and M stage (P=0.004) were independent prognostic factors.
ELCNC is a rare subtype of esophageal neuroendocrine carcinoma. The clinicopathological features differ from those of other esophageal carcinomas. Prognosis may be closely related to age and M stage.
食管大细胞神经内分泌癌（ELCNC）似乎是一种罕见的胃肠道恶性肿瘤。迄今为止，其临床病理特征和预后尚未得到深入研究。
从监测、流行病学和最终结果（SEER）数据库中提取患有ELCNC患者的数据，然后与食管小细胞神经内分泌癌（ESCNC）或食管鳞状细胞癌（ESCC）患者的信息进行评估和比较。我们使用单因素和多因素分析来准确检测独立的预后因素。
2004年至2015年期间获得了36例ELCNC患者的数据。与ESCNC和ESCC患者相比，ECLNC患者的平均生存时间比ESCC患者差，但与ESCNC相似。因此，ELCNC与ESCNC和ESCC相比具有明显不同的临床病理特征。单因素和多因素分析显示，年龄（P=0.001）和M分期（P=0.004）是独立的预后因素。
ELCNC是食管神经内分泌癌的一种罕见亚型。其临床病理特征与其他食管癌不同。预后可能与年龄和M分期密切相关。
