Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi, Osaka, 558-8585, Japan.
Org Biomol Chem. 2020 Feb 26;18(8):1563-1566. doi: 10.1039/d0ob00125b.
The nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides have been developed. This umpolung reaction allows the regioselective introduction of phenyl and alkyl groups to a vinylketene N,O-acetal, which is generated in situ from an α,β-unsaturated N-alkoxyamide, followed by N-O bond cleavage in a two-step, one-pot process.
已开发出α,β-不饱和酰胺的亲核γ-芳基化和γ-烷基化反应。该反转反应允许在 vinylketene N,O-缩醛中区域选择性地引入苯基和烷基，该缩醛是由α,β-不饱和 N-烷氧基酰胺原位生成的，随后在两步一锅法中通过 N-O 键断裂来实现。
