骨髓驻留细胞作为骨转移微环境的作用。

The Roles of Bone Marrow-Resident Cells as a Microenvironment for Bone Metastasis.

机构信息

Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC, USA.

出版信息

Adv Exp Med Biol. 2020;1226:57-72. doi: 10.1007/978-3-030-36214-0_5.

DOI:10.1007/978-3-030-36214-0_5

PMID:32030676

Abstract

It has been appreciated that the cross talk between bone metastatic cancer cells and bone marrow microenvironment influence one another to worsen bone metastatic disease progression. Bone marrow contains various cell types, including (1) cells of mesenchymal origin (e.g., osteoblasts, osteocytes, and adipocytes), (2) cells of hematopoietic origin (e.g., osteoclast and immune cells), and (3) others (e.g., endothelial cells and nerves). The recent studies have enabled us to discover many important cancer-derived factors responsible for the development of bone metastasis. However, many critical questions regarding the roles of bone microenvironment in bone metastatic progression remain elusive. To answer these questions, a deeper understanding of the cross talk between bone metastatic cancer and bone marrow microenvironment is clearly warranted.

摘要

已经认识到，骨转移癌细胞与骨髓微环境之间的串扰相互影响，使骨转移疾病的进展恶化。骨髓包含各种细胞类型，包括（1）间充质来源的细胞（例如成骨细胞、骨细胞和成脂细胞），（2）造血来源的细胞（例如破骨细胞和免疫细胞），以及（3）其他细胞（例如内皮细胞和神经）。最近的研究使我们能够发现许多负责骨转移发展的重要癌症衍生因子。然而，关于骨微环境在骨转移进展中的作用的许多关键问题仍然难以捉摸。为了回答这些问题，显然需要更深入地了解骨转移癌与骨髓微环境之间的串扰。