Personalised Cancer Therapeutics Lab, The Kinghorn Cancer Centre, Sydney, NSW, Australia.
Faculty of Medicine, St Vincent's Clinical School, University of NSW, Sydney, NSW, Australia.
Adv Exp Med Biol. 2020;1223:99-127. doi: 10.1007/978-3-030-35582-1_6.
The Rho-ROCK signaling network has a range of specialized functions of key biological importance, including control of essential developmental processes such as morphogenesis and physiological processes including homeostasis, immunity, and wound healing. Deregulation of Rho-ROCK signaling actively contributes to multiple pathological conditions, and plays a major role in cancer development and progression. This dynamic network is critical in modulating the intricate communication between tumor cells, surrounding diverse stromal cells and the matrix, shaping the ever-changing microenvironment of aggressive tumors. In this chapter, we overview the complex regulation of the Rho-ROCK signaling axis, its role in health and disease, and analyze progress made with key approaches targeting the Rho-ROCK pathway for therapeutic benefit. Finally, we conclude by outlining likely future trends and key questions in the field of Rho-ROCK research, in particular surrounding Rho-ROCK signaling within the tumor microenvironment.
Rho-ROCK 信号网络具有一系列关键生物学重要性的专门功能，包括控制形态发生等基本发育过程和体内平衡、免疫和伤口愈合等生理过程。Rho-ROCK 信号的失调积极促成多种病理状况，并在癌症发展和进展中起主要作用。这个动态网络对于调节肿瘤细胞之间、周围不同基质细胞和基质之间复杂的通信至关重要，塑造了侵袭性肿瘤不断变化的微环境。在本章中，我们概述了 Rho-ROCK 信号轴的复杂调节、它在健康和疾病中的作用，并分析了针对 Rho-ROCK 途径进行治疗获益的关键方法所取得的进展。最后，我们通过概述 Rho-ROCK 研究领域中可能的未来趋势和关键问题来总结，特别是围绕肿瘤微环境中的 Rho-ROCK 信号。
