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Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):8. doi: 10.1167/iovs.61.2.8.
Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO).
We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first- or second-order branches of the retinal veins associate, using a viewing angle of 12 × 12 mm2 in optical coherence tomography angiography (OCTA).
We reviewed 1349 and 1276 AV crossings in BRVO patients and control subjects, respectively. The proportions of venous overcrossing were 26.5%, 28.6%, and 26.8% at non-causative crossings in BRVO eyes, non-BRVO fellow eyes, and unaffected control eyes, respectively; however, the rate of venous overcrossings at the causative crossings was 45.1%. In OCTA analyses, we divided the branches into macular- or non-macular veins. The rate of venous overcrossing was 52.5% at causative crossings in major BRVO but was 28.6% in macular BRVO. Odds ratios for whether venous overcrossing was a risk factor for BRVO were 3.09 (95% confidence interval [CI], 1.96-4.88) and 0.94 (95% CI, 0.44-2.00) for non-macular veins and macular veins, respectively. The patients with major BRVO caused by venous overcrossing were younger than patients for whom the cause was arterial overcrossing (P < 0.001). The onset of macular BRVO did not differ between crossing patterns at causative crossings (P = 0.60).
In eyes with BRVO, venous overcrossing was a common angiographic feature at causative crossings and might be a risk factor for major BRVO onset.
研究动静脉（AV）交叉处的血管与分支视网膜静脉阻塞（BRVO）发病之间的关系。
我们纳入了 78 例主要 BRVO 患者、35 例黄斑 BRVO 患者和 110 例无 BRVO 的对照患者，使用光学相干断层扫描血管造影（OCTA）观察 12×12mm2 的视角，确定视网膜静脉的一级或二级分支在 AV 交叉处的血管位置。
我们分别在 BRVO 患者和对照患者中复查了 1349 处和 1276 处 AV 交叉。BRVO 眼、非 BRVO 对侧眼和无影响对照眼中非致病交叉处静脉越过的比例分别为 26.5%、28.6%和 26.8%，但致病交叉处的静脉越过率为 45.1%。在 OCTA 分析中，我们将分支分为黄斑或非黄斑静脉。在主要 BRVO 的致病交叉处，静脉越过的发生率为 52.5%，而在黄斑 BRVO 中则为 28.6%。静脉越过是否为 BRVO 危险因素的优势比（OR）分别为非黄斑静脉 3.09（95%置信区间[CI]，1.96-4.88）和黄斑静脉 0.94（95%CI，0.44-2.00）。静脉越过引起的主要 BRVO 患者比动脉越过引起的 BRVO 患者年轻（P<0.001）。致病交叉处的穿越模式对黄斑 BRVO 的发病没有影响（P=0.60）。
在 BRVO 眼中，静脉越过在致病交叉处是一种常见的血管造影特征，可能是主要 BRVO 发病的危险因素。
