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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Castro-e-Silva E, Antunes-Rodrigues J

Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Brasil.

Braz J Med Biol Res. 1988;21(2):345-51.

The participation of the central histaminergic system in basal and opioid-induced prolactin secretion in male rats was investigated. 2. Central injections of cimetidine, an H2 antihistaminic, reduced basal plasma prolactin levels from 5.08 +/- 0.76 to 3.11 +/- 0.50 ng/ml (N = 10) while diphenhydramine, an H1 antihistaminic, had no effect. 3. Intracerebroventricular injections of FK 33824, a synthetic opioid peptide, produced a dose-dependent increase of prolactin secretion. This effect was partially blocked (-50%) by pretreatment with 20 ng diphenhydramine 15 min before administration of the opioid peptide. Cimetidine pretreatment failed to modify the prolactin rise in this case. 4. We conclude that brain histaminergic pathways exert a stimulatory tone on basal prolactin secretion which is mediated by H2 receptors and that the opioid-induced prolactin rise depends at least in part on activation of H1-histamine receptors.

研究了中枢组胺能系统在雄性大鼠基础催乳素分泌及阿片类药物诱导的催乳素分泌中的作用。2. 中枢注射H2抗组胺药西咪替丁可使基础血浆催乳素水平从5.08±0.76降至3.11±0.50 ng/ml（N = 10），而H1抗组胺药苯海拉明则无此作用。3. 脑室内注射合成阿片肽FK 33824可使催乳素分泌呈剂量依赖性增加。在给予阿片肽前15分钟用20 ng苯海拉明预处理可部分阻断（-50%）此效应。在这种情况下，西咪替丁预处理未能改变催乳素的升高。4. 我们得出结论，脑组胺能通路对基础催乳素分泌发挥刺激作用，这由H2受体介导，且阿片类药物诱导的催乳素升高至少部分取决于H1组胺受体的激活。

Castro-e-Silva E, Antunes-Rodrigues J

Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Brasil.

Braz J Med Biol Res. 1988;21(2):345-51.

The participation of the central histaminergic system in basal and opioid-induced prolactin secretion in male rats was investigated. 2. Central injections of cimetidine, an H2 antihistaminic, reduced basal plasma prolactin levels from 5.08 +/- 0.76 to 3.11 +/- 0.50 ng/ml (N = 10) while diphenhydramine, an H1 antihistaminic, had no effect. 3. Intracerebroventricular injections of FK 33824, a synthetic opioid peptide, produced a dose-dependent increase of prolactin secretion. This effect was partially blocked (-50%) by pretreatment with 20 ng diphenhydramine 15 min before administration of the opioid peptide. Cimetidine pretreatment failed to modify the prolactin rise in this case. 4. We conclude that brain histaminergic pathways exert a stimulatory tone on basal prolactin secretion which is mediated by H2 receptors and that the opioid-induced prolactin rise depends at least in part on activation of H1-histamine receptors.

研究了中枢组胺能系统在雄性大鼠基础催乳素分泌及阿片类药物诱导的催乳素分泌中的作用。2. 中枢注射H2抗组胺药西咪替丁可使基础血浆催乳素水平从5.08±0.76降至3.11±0.50 ng/ml（N = 10），而H1抗组胺药苯海拉明则无此作用。3. 脑室内注射合成阿片肽FK 33824可使催乳素分泌呈剂量依赖性增加。在给予阿片肽前15分钟用20 ng苯海拉明预处理可部分阻断（-50%）此效应。在这种情况下，西咪替丁预处理未能改变催乳素的升高。4. 我们得出结论，脑组胺能通路对基础催乳素分泌发挥刺激作用，这由H2受体介导，且阿片类药物诱导的催乳素升高至少部分取决于H1组胺受体的激活。