Segrestaa J M, Gueris J, Lefaucheur C, Orriere P
Pathol Biol (Paris). 1982 Oct;30(8):715-8.
Histamine is considered as a neurotransmitter, since it is present in hypothalamus and pituitary gland. It has been reported to stimulate prolactin (PRL) release in rats and humans; it seems to be involved in the control of LH release in rats. But cimetidine, an H2 antagonist also induces PRL release in humans. To investigate the relationship between the PRL secretion and possible histaminergic pathways, the response of PRL and LH was studied for 180 minutes in 10 normal subjects (5 men, 5 women) after H1 antagonist (diphenhydramine 50 mg iv), H2 antagonist (cimetidine 300 mg iv) and placebo. Diphenhydramine and placebo injection resulted in a decrease of PRL from 0800 until 11.00 hours, suggesting a spontaneous diurnal variation. Cimetidine induced a short but significant rise of PRL before a similar diurnal secretory pattern. LH levels were unaffected by H1 and H2 antagonists. These data suggest that PRL and LH secretion in humans is unresponsive to H1 histaminergic pathways. The specific action of cimetidine remains to be defined.
组胺被认为是一种神经递质，因为它存在于下丘脑和垂体中。据报道，它能刺激大鼠和人类的催乳素（PRL）释放；它似乎参与了大鼠促黄体生成素（LH）释放的控制。但是，H2拮抗剂西咪替丁也能诱导人类的PRL释放。为了研究PRL分泌与可能的组胺能途径之间的关系，对10名正常受试者（5名男性，5名女性）在静脉注射H1拮抗剂（苯海拉明50毫克）、H2拮抗剂（西咪替丁300毫克）和安慰剂后180分钟内PRL和LH的反应进行了研究。苯海拉明和安慰剂注射导致PRL从08:00到11:00下降，提示存在自发的昼夜变化。西咪替丁在类似的昼夜分泌模式之前诱导PRL出现短暂但显著的升高。LH水平不受H1和H2拮抗剂的影响。这些数据表明，人类的PRL和LH分泌对H1组胺能途径无反应。西咪替丁的具体作用仍有待确定。
