Vigliarolo Laura, Arias Barbara, Suárez Mariana, Van Haute Evert, Kovacec Verónica, Lopardo Horacio, Bonofiglio Laura, Mollerach Marta
Cátedra de Microbiología Clínica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata. Provincia de Buenos Aires, Argentina.
Departamento de Microbiología, Inmunología, Biotecnología y Genética. Cátedra de Microbiología. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Ciudad Autónoma de Buenos Aires, Argentina.
J Infect Dev Ctries. 2019 Jan 31;13(1):77-82. doi: 10.3855/jidc.10503.
Streptococcus agalactiae (group B streptococcus, GBS) is a recognized urinary pathogen both in males and pregnant or non-pregnant women. Data regarding GBS serotypes recovered from urinary tract infections (UTIs) are scarce. The aim of this study was to describe the clinical and microbiological characteristics of UTIs caused by GBS in adult patients in Argentina.
A prospective multicenter study involving 86 centers was conducted in Argentina between July 1st, 2014 and June 30th, 2015. Antimicrobial susceptibility and serotype distribution of GBS isolated from the urinary tract of adult patients were determined. Susceptibility tests were performed by the disk diffusion and/or agar dilution methods. Epidemiological and clinical characteristics of the patients were considered to identify associated comorbilities.
Seven hundred and one GBS were sent to the reference laboratory in the above mentioned period, however, only 211 fulfilled our selection criteria (demographic data availability, underlying diseases reported, colony counts greater than 105 CFU/mL, single organism isolated from the urine sample). No penicillin-resistant GBS was found but fluoroquinolone resistance was high (12.8%), especially among GBS isolated from men and non-pregnant women. UTIs due to GBS were associated to underlying diseases in men and non-pregnant women, particularly diabetes mellitus. Most of the isolates showed serotypes Ia and III.
GBS are still susceptible to penicillin but fluoroquinolone resistance is a growing concern, at least in Argentina. There are underlying conditions that could be associated to urinary infections caused by GBS.
无乳链球菌（B族链球菌，GBS）是男性、孕妇或非孕妇中公认的尿路病原体。关于从尿路感染（UTI）中分离出的GBS血清型的数据很少。本研究的目的是描述阿根廷成年患者中由GBS引起的UTI的临床和微生物学特征。
2014年7月1日至2015年6月30日在阿根廷进行了一项涉及86个中心的前瞻性多中心研究。确定了从成年患者尿路分离出的GBS的抗菌药敏性和血清型分布。药敏试验采用纸片扩散法和/或琼脂稀释法进行。考虑患者的流行病学和临床特征以确定相关的合并症。
在上述期间，有701株GBS被送至参考实验室，但只有211株符合我们的选择标准（可获得人口统计学数据、报告有基础疾病、菌落计数大于105 CFU/mL、从尿液样本中分离出单一菌株）。未发现耐青霉素的GBS，但氟喹诺酮耐药率很高（12.8%），尤其是在从男性和非孕妇中分离出的GBS中。男性和非孕妇中由GBS引起的UTI与基础疾病有关，尤其是糖尿病。大多数分离株显示血清型Ia和III。
GBS对青霉素仍然敏感，但氟喹诺酮耐药是一个日益令人担忧的问题，至少在阿根廷是这样。存在一些可能与GBS引起的尿路感染相关的基础疾病。
