Department of Biology, University of Louisiana at Lafayette, Lafayette, LA, USA 70504.
New Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, USA 70560.
J Diabetes Res. 2022 May 17;2022:3588297. doi: 10.1155/2022/3588297. eCollection 2022.
This systematic review addresses the central research question, "what is known from the published, peer-reviewed literature about the impact of diabetes on the risk of bacterial urinary tract infections (UTI)?" We examine the results from laboratory studies where researchers have successfully adapted mouse models of diabetes to study the pathophysiology of ascending UTI. These studies have identified molecular and cellular effectors shaping immune defenses against infection of the diabetic urinary tract. In addition, we present evidence from clinical studies that in addition to diabetes, female gender, increased age, and diabetes-associated hyperglycemia, glycosuria, and immune impairment are important risk factors which further increase the risk of UTI in diabetic individuals. Clinical studies also show that the uropathogenic genera causing UTI are largely similar between diabetic and nondiabetic individuals, although diabetes significantly increases risk of UTI by drug-resistant uropathogenic bacteria.
“已发表的同行评议文献中关于糖尿病对细菌性尿路感染（UTI）风险的影响有哪些了解？”我们研究了实验室研究的结果，研究人员成功地使糖尿病小鼠模型适应，以研究上行性 UTI 的病理生理学。这些研究确定了塑造针对糖尿病泌尿道感染的免疫防御的分子和细胞效应物。此外，我们还提供了来自临床研究的证据，表明除糖尿病外，女性、年龄增长、糖尿病相关的高血糖、糖尿和免疫功能障碍也是重要的风险因素，进一步增加了糖尿病患者 UTI 的风险。临床研究还表明，引起 UTI 的尿病原体在糖尿病患者和非糖尿病患者中大致相似，尽管糖尿病会显著增加耐药性尿病原体引起的 UTI 风险。
