较低层次加工的特性调节去甲肾上腺素系统在反应抑制过程中的作用。
Properties of lower level processing modulate the actions of the norepinephrine system during response inhibition.
机构信息
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Germany; MS Centre Dresden, Centre of Clinical Neuroscience, Department of Neurology, Faculty of Medicine, TU Dresden, Germany.
MS Centre Dresden, Centre of Clinical Neuroscience, Department of Neurology, Faculty of Medicine, TU Dresden, Germany.
出版信息
Biol Psychol. 2020 Apr;152:107862. doi: 10.1016/j.biopsycho.2020.107862. Epub 2020 Feb 4.
We ask whether actions of the norepinephrine (NE) system during response inhibition are affected by properties of lower level sensory stimulus processing. We used a somato-sensory Go/Nogo task and combined ERP recordings with pupil diameter recordings as an index of NE system activity. The Go/Nogo task was designed to achieve processing of tactile stimuli predominantly over primary somatosensory (SI) and secondary somatosensory (SII) areas. The data show that response inhibition was better when stimuli were processed via SII, compared to SI areas. This was reflected by variations in the Nogo-N2/P3 associated with anterior cingulate structures. Correlations with the pupil diameter data, indicting modulations of the NE system during inhibitory control processes, were only evident when SI sensory areas were involved. These dissociable modulatory effects were associated with activations in the superior frontal gyrus. Actions of the NE system during response inhibition are modulated by properties of lower level processing.
我们探讨了在反应抑制过程中去甲肾上腺素（NE）系统的活动是否受到较低水平感觉刺激处理特性的影响。我们使用了躯体感觉 Go/Nogo 任务，并结合 ERP 记录和瞳孔直径记录作为 NE 系统活动的指标。Go/Nogo 任务旨在实现主要通过初级躯体感觉（SI）和次级躯体感觉（SII）区域处理触觉刺激。数据显示，与 SI 区域相比，当刺激通过 SII 处理时，反应抑制更好。这反映在与扣带前结构相关的 Nogo-N2/P3 的变化上。与瞳孔直径数据的相关性表明，在抑制控制过程中 NE 系统的调制仅在涉及 SI 感觉区域时才明显。这些可分离的调节效应与额上回的激活有关。在反应抑制过程中，NE 系统的作用受到较低水平处理特性的调节。
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