Dong Jie, Lu Chengrou, Chen Chuansheng, Li Huiling, Liu Xiaoyu, Mei Leilei
Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application and School of Psychology, South China Normal University, Guangzhou, China.
Department of Psychological Science, University of California, Irvine, CA, USA.
Neuroscience. 2020 Mar 15;430:94-104. doi: 10.1016/j.neuroscience.2020.01.024. Epub 2020 Feb 4.
Previous studies have identified the ventral and dorsal brain regions that respectively support semantic and non-semantic phonological access. Nevertheless, the specific role of the left occipitotemporal cortex (lOTC) in the two pathways of phonological access is ambiguous. To address that question, the present study compared word reading in Chinese (presumably relying on the semantic pathway) with that in English (presumably relying on the non-semantic pathway). Results revealed a clear dissociation in the involvement of the anterior and posterior lOTC in semantic and non-semantic phonological access. Specifically, the anterior lOTC showed greater activation for Chinese than for English, whereas the posterior lOTC showed greater activation for English than for Chinese. More importantly, both psychophysiological interaction analysis and resting-state functional connectivity analysis showed that the anterior lOTC was functionally connected to the ventral brain regions (e.g., left anterior fusiform gyrus, anterior temporal lobe, and ventral inferior frontal gyrus), whereas the posterior lOTC was functionally connected to the dorsal brain regions (e.g., left posterior superior temporal gyrus, supramarginal gyrus, and dorsal inferior frontal gyrus). These results suggest that the anterior and posterior lOTC are involved in semantic and non-semantic phonological access, respectively.
先前的研究已经确定了分别支持语义和非语义语音通达的腹侧和背侧脑区。然而，左侧枕颞叶皮层（lOTC）在语音通达的两条通路中的具体作用尚不明确。为了解决这个问题，本研究比较了中文（可能依赖语义通路）和英文（可能依赖非语义通路）的单词阅读。结果显示，lOTC的前部和后部在语义和非语义语音通达中的参与存在明显分离。具体而言，lOTC的前部在阅读中文时比阅读英文时表现出更强的激活，而lOTC的后部在阅读英文时比阅读中文时表现出更强的激活。更重要的是，心理生理交互分析和静息态功能连接分析均表明，lOTC的前部与腹侧脑区（如左侧前梭状回、颞叶前部和腹侧额下回）功能相连，而lOTC的后部与背侧脑区（如左侧后颞上回、缘上回和背侧额下回）功能相连。这些结果表明，lOTC的前部和后部分别参与语义和非语义语音通达。
