Kristoffersson U, Heim S, Mandahl N, Olsson H, Akerman M, Mitelman F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Cancer Genet Cytogenet. 1988 Dec;36(2):173-6. doi: 10.1016/0165-4608(88)90141-0.
A 62-year-old previously healthy woman presented with a centroblastic non-Hodgkin's lymphoma in the thyroid. Chromosome analysis revealed two unrelated clones, 47,XX,+5 and 46,XX,-14,+der(14)t(5;14)(q11;q32). The two clones may reflect a polyclonal origin, or they may be the descendants of the same neoplastically rearranged cell. In the latter case, the clonal aberrations are either secondary to an event detectable only at the molecular level, or one of them is a primary cytogenetic event while the other arose through clonal evolution with loss of the primary aberration. The best candidate for the primary change would be trisomy 5. Trisomy 5 has previously been associated with lymphomas with diffuse, large, noncleaved morphology, a group within the Working Formulation largely equivalent to centroblastic lymphomas in the Kiel classification. Our findings thus support the notion that trisomy 5 may be associated with centroblastic/diffuse, large, noncleaved lymphomas.
一名62岁既往健康的女性被诊断为甲状腺中心母细胞性非霍奇金淋巴瘤。染色体分析显示两个不相关的克隆，即47,XX,+5和46,XX,-14,+der(14)t(5;14)(q11;q32)。这两个克隆可能反映多克隆起源，或者它们可能是同一肿瘤性重排细胞的后代。在后一种情况下，克隆畸变要么继发于仅在分子水平可检测到的事件，要么其中一个是原发性细胞遗传学事件，而另一个则是通过原发性畸变丢失的克隆进化产生的。原发性改变的最佳候选者可能是5号染色体三体。5号染色体三体先前已与具有弥漫性、大细胞、无裂核形态的淋巴瘤相关，在工作分类中这一组大体上相当于基尔分类中的中心母细胞性淋巴瘤。因此，我们的研究结果支持5号染色体三体可能与中心母细胞性/弥漫性、大细胞、无裂核淋巴瘤相关这一观点。
