口腔白斑患者淋巴细胞中的姐妹染色单体交换

Sister chromatid exchanges in the lymphocytes of patients with oral leukoplakia.

作者信息

Ghosh R, Sharma J K, Ghosh P K

机构信息

Department of Anthropology, University of Delhi, India.

出版信息

Cancer Genet Cytogenet. 1988 Dec;36(2):177-82. doi: 10.1016/0165-4608(88)90142-2.

DOI:10.1016/0165-4608(88)90142-2

PMID:3203306

Abstract

The incidence of sister chromatid exchange (SCE) was investigated in lymphocyte chromosomes of 59 patients with oral leukoplakia and 65 age- and sex-matched nonsmoking controls. The frequency of SCE was found to be 8.61 +/- 1.89 in patients with oral leukoplakia, which was significantly higher than the mean SCE value of 5.58 +/- 1.26 observed in normal controls. The frequency of SCE in patients with oral leukoplakia addicted to the single habit of betel with tobacco chewing, bidi/cigarette smoking, and combined habits of chewing and smoking of tobacco were found to be 7.95 +/- 1.63, 8.17 +/- 1.66, and 9.23 +/- 2.14, respectively. These values were also significantly higher as compared to the SCE values observed in normal controls.

摘要

对59例口腔白斑患者及65名年龄和性别匹配的不吸烟对照者的淋巴细胞染色体进行姐妹染色单体交换（SCE）发生率调查。发现口腔白斑患者的SCE频率为8.61±1.89，显著高于正常对照者观察到的平均SCE值5.58±1.26。发现有咀嚼槟榔加烟草、抽比迪烟/香烟单一习惯以及咀嚼和吸烟联合习惯的口腔白斑患者的SCE频率分别为7.95±1.63、8.17±1.66和9.23±2.14。与正常对照者观察到的SCE值相比，这些值也显著更高。