Gupta P C
Br J Cancer. 1984 Oct;50(4):527-31. doi: 10.1038/bjc.1984.210.
In a house-to-house survey in Ernakulam district, Kerala, India, 12,213 tobacco users were interviewed about the details of their tobacco usage and examined for the presence of leukoplakia. The frequency of tobacco habit was associated with the prevalence of leukoplakia indicating a positive dose-response relationship. The dose-response relationship remained significant, taking age, sex, and the type of tobacco habit into account. After adjusting for all these variables jointly the association still remained significant. The dose-response relationship was stronger for the smoking habit than for the chewing habit. A weaker relationship in the chewing habit was not due to the duration of chewing habit or the habit of retaining the betel quid in the mouth while sleeping. Thus the dose-response relationship, although significant, was different for tobacco smoking and chewing habits.
在印度喀拉拉邦埃尔讷古勒姆区进行的挨家挨户调查中,对12213名烟草使用者就其烟草使用细节进行了访谈,并检查了是否存在白斑。烟草使用习惯的频率与白斑患病率相关,表明存在正剂量反应关系。考虑到年龄、性别和烟草使用习惯类型后,剂量反应关系仍然显著。在对所有这些变量进行联合调整后,这种关联仍然显著。吸烟习惯的剂量反应关系比咀嚼习惯更强。咀嚼习惯中较弱的关系并非由于咀嚼习惯的持续时间或睡觉时在口中保留槟榔块的习惯。因此,剂量反应关系虽然显著,但吸烟和咀嚼习惯的情况有所不同。