Roomi M W, Vincent S H, Farber E, Muller-Eberhard U
Department of Pathology, University of Toronto, Ontario, Canada.
Cancer Lett. 1988 Dec 1;43(1-2):55-8. doi: 10.1016/0304-3835(88)90213-3.
Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P less than 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas (10-12 months). This finding is in accordance with the previously reported reduced heme content of hepatocyte nodules and is consistent with the postulated role for HBP in intracellular heme transport and distribution. The immunoreactive levels of the glutathione S-transferase isozymes (GST) which like HBP bind heme, were elevated 2-fold (P less than 0.01) in early and late hepatocyte nodules and were unchanged in hepatocellular carcinomas.
使用抗性肝细胞模型在雄性Fischer大鼠中诱导出肝细胞结节和肝细胞癌。在早期肝细胞结节（25周）和肝细胞癌（10 - 12个月）中，血红素结合Z蛋白（HBP）的免疫反应性胞质水平降低了56%（P < 0.001；双侧t检验）。这一发现与先前报道的肝细胞结节血红素含量降低一致，并且与HBP在细胞内血红素运输和分布中的假定作用相符。谷胱甘肽S - 转移酶同工酶（GST）的免疫反应性水平，像HBP一样能结合血红素，在早期和晚期肝细胞结节中升高了2倍（P < 0.01），而在肝细胞癌中没有变化。
