Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Int J Environ Res Public Health. 2020 Feb 5;17(3):1008. doi: 10.3390/ijerph17031008.
Rotavirus (RV) infections are a leading cause of severe gastroenteritis in children, and vaccination is currently recommended in Italy, according to the National Immunization Plan 2017-2019. The objective of this study was to describe the epidemiological and molecular RV surveillance in the pediatric population of Perugia province, Umbria. Between September 2007 and August 2018, 663 RV-positive stool specimens were collected from children <15 years of age presenting with gastroenteritis to the emergency room of the Perugia province hospitals who were then hospitalized. Yearly hospitalization rates were expressed per 100,000 persons, and denominators were extrapolated from the National Institute of Statistics. During the 10-year surveillance, the epidemiological trend was fluctuating but slightly decreasing (Max: 89.7 per 100,000 in 2010/2011; Min: 34.8 per 100,000 in 2017/2018). The hospitalization rate was higher in males and in children under five years of age. Among common genotypes, G1P[8] was prevalent most of the years. The uncommon G12P [8] genotype emerged and was the most common in 2012/2013 (58.2%). Afterwards, its circulation remained high. As the Umbria Region started vaccinating from the 2018 birth cohort, our study reviewed pre-vaccination data and will help to assess the protection induced by vaccination and its effect on circulating strains.
轮状病毒（RV）感染是导致儿童严重胃肠炎的主要原因，根据 2017-2019 年国家免疫计划，意大利目前推荐接种疫苗。本研究的目的是描述佩鲁贾省儿科人群中轮状病毒的流行病学和分子监测情况。2007 年 9 月至 2018 年 8 月，在佩鲁贾省医院急诊室就诊的胃肠炎患儿<15 岁，共采集 663 份 RV 阳性粪便标本，随后住院。每年的住院率用每 10 万人表示，分母由国家统计局推断得出。在 10 年的监测期间，流行趋势波动但略有下降（2010/2011 年最高：89.7/10 万；2017/2018 年最低：34.8/10 万）。男性和 5 岁以下儿童的住院率较高。在常见基因型中，G1P[8]在大多数年份都很常见。不常见的 G12P [8]基因型出现并在 2012/2013 年最为常见（58.2%）。此后，其传播仍保持高位。由于翁布里亚地区从 2018 年出生的队列开始接种疫苗，我们的研究回顾了接种疫苗前的数据，这将有助于评估疫苗诱导的保护作用及其对流行株的影响。
