Mattei Antonella, Sbarbati Margherita, Fiasca Fabiana, Angelone Anna Maria, Mazzei Maria Chiara, di Orio Ferdinando
a Medical Statistics; Section of Public Health ; Department of Life, Health and Environmental Sciences; University of L'Aquila ; L'Aquila , Italy.
b Department of Maternal and Child Health ; Local Health Unit of Rieti ; Rieti , Italy.
Hum Vaccin Immunother. 2016;12(2):534-9. doi: 10.1080/21645515.2015.1081726.
AGE severity is linked to etiology, and Rotavirus (RV) accounts for most of severe cases. In 2009 the World Health Organization recommended RV vaccination for all children. Worldwide a number of Countries implemented RV vaccination in their pediatric immunisation programmes, but only a limited number in Europe. This study was designed to estimate the proportion of RVGE among children aged <6 y who were diagnosed with AGE and admitted to hospitals in Italy during the years 2005-2012. A total of 334,982 hospital discharge forms were collected, being 79,344 hospitalizations associated with RV. The average hospitalization rate (HR) was 146/100,000 children for RVGE in primary diagnosis (PD) and 150/100,000 children for RVGE in secondary diagnosis (SD). Since 2008 the RVGE hospitalization figures and rates (HRs) in SD exceed those in PD. The majority of RVGE hospitalizations (33.67%) were reported among children aged ≤ 2 years. Despite some limitations due to the hospital discharge database (HDD) synthetic contents and low potential for clinical interpretation, the analysis of national HDD, including PD and SD, documents that RV still represents a consistent cause of pediatric hospitalizations in Italy.
急性胃肠炎（AGE）的严重程度与病因有关，轮状病毒（RV）是大多数严重病例的病因。2009年，世界卫生组织建议为所有儿童接种RV疫苗。在全球范围内，许多国家在其儿科免疫规划中实施了RV疫苗接种，但在欧洲只有少数国家这样做。本研究旨在估计2005 - 2012年期间在意大利被诊断为AGE并住院的6岁以下儿童中RV胃肠炎（RVGE）的比例。共收集了334,982份医院出院表格，其中79,344例住院与RV有关。RVGE在初次诊断（PD）中的平均住院率（HR）为每100,000名儿童146例，在二次诊断（SD）中的平均住院率为每100,000名儿童150例。自2008年以来，SD中的RVGE住院数字和住院率（HRs）超过了PD中的数字和住院率。大多数RVGE住院病例（33.67%）报告于≤2岁的儿童中。尽管医院出院数据库（HDD）的综合内容存在一些局限性且临床解释潜力较低，但对包括PD和SD在内的国家HDD的分析表明，RV仍然是意大利儿科住院的一个重要原因。
