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肺出血致喘吻蝮咬伤后生命威胁的并发症。

A life-threatening complication due to pulmonary haemorrhage following hump-nosed viper bite.

机构信息

University Medical Unit, Colombo South Teaching Hospital, Kalubowila, Colombo, Sri Lanka.

Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.

出版信息

BMC Pulm Med. 2020 Feb 7;20(1):35. doi: 10.1186/s12890-020-1070-9.

Abstract

BACKGROUND

Hump-nosed viper bite, the commonest venomous snake bite in Sri Lanka, is associated with significant morbidity. Specific anti-venom is not available for hump-nosed viper envenomation which is usually managed with supportive treatment. Pulmonary haemorrhage is an unusual manifestation of hump-nosed viper bite. Here we present a case of hump-nosed viper envenomation which complicated by pulmonary haemorrhage and was successfully treated with systemic steroids. To the best of our knowledge, it has not been reported in the literature before.

CASE PRESENTATION

A previously healthy 55-year-old man presented to the local hospital 18 h after a hump-nosed viper bite. He developed bilateral severe pulmonary haemorrhages, evidenced by rapid desaturation which needed intubation and mechanical ventilation, bleeding from the endotracheal tube and bilateral alveolar shadows in a chest x-ray. He had no other bleeding manifestations. Because of the life-threatening situation, he was treated with methylprednisolone pulse therapy. There was a rapid improvement of hypoxia with a resolution of x-ray changes. He was successfully weaned off from the ventilation after 24 h.

CONCLUSION

This case highlights the importance of suspecting pulmonary haemorrhage in a patient who develops desaturation and alveolar shadow following hump-nosed viper bite even in the absence of other bleeding manifestation. Early and timely treatment with systemic steroid can be lifesaving in such patients.

摘要

背景

在斯里兰卡,最常见的毒蛇咬伤是扁鼻蝰蛇咬伤,其发病率较高。目前还没有针对扁鼻蝰蛇咬伤的特效解毒剂,通常采用支持性治疗。肺部出血是扁鼻蝰蛇咬伤的一种罕见表现。在此,我们报告一例因扁鼻蝰蛇咬伤而并发肺部出血的病例,该病例经全身类固醇治疗后成功治愈。据我们所知,目前尚未有文献报道过此类病例。

病例介绍

一名 55 岁的既往健康男性在被扁鼻蝰蛇咬伤后 18 小时就诊于当地医院。他出现双侧严重的肺部出血,表现为迅速的血氧饱和度下降,需要气管插管和机械通气,气管内出血和胸部 X 线显示双侧肺泡阴影。他没有其他出血表现。由于存在危及生命的情况,他接受了甲泼尼龙脉冲治疗。缺氧情况迅速改善,X 线改变得到缓解。他在 24 小时后成功脱离呼吸机。

结论

本病例强调了在扁鼻蝰蛇咬伤后出现血氧饱和度下降和肺泡阴影的患者中,即使没有其他出血表现,也应怀疑肺部出血的重要性。早期及时给予全身类固醇治疗对这类患者可能具有救命作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e8f/7006151/0ceac196b50e/12890_2020_1070_Fig1_HTML.jpg

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