Ruiz Álvaro Jesús Gómez, López Víctor López, Campos Ricardo Robles, Conesa Asunción López, Brusadin Roberto, Martínez David Ferreras, Paricio Pascual Parrilla
General and Digestive Surgery, Virgen de la Arrixaca Clinic and University Hospital, El Palmar, Murcia, Spain.
General and Digestive Surgery, Virgen de la Arrixaca Clinic and University Hospital, El Palmar, Murcia, Spain.
Transplant Proc. 2020 Mar;52(2):594-595. doi: 10.1016/j.transproceed.2019.11.036. Epub 2020 Feb 6.
Hepatic adenomatosis is defined as the presence of more than 10 adenomatous lesions seated on a healthy liver. The most frequent complication is bleeding, presenting a risk of malignant neoplasms of less than 10%.
We present a case of a 28-year-old woman with polycystic ovary syndrome treated with oral contraceptives for 10 years. Ultrasonography showed benign mass, and biopsy specimen showed adenoma. Nuclear magnetic resonance showed multiple hepatic adenomatosis with a large nodule in the right hepatic lobe of 21 cm and another 10 nodules in segments II, III, IVa, IVb, VIII-VII, and VI. A computed tomography scan with volumetry was performed where a future liver remnant volume (FLRV) of 30% was observed with an FLRV body weight ratio of 0.34%. Surgery was planned in 2 stages. First, the lesions of sections II-III, IVa, and IVb were resected and a ligature of right port vein and a tourniquet in Cantlie line were performed. At 15 days the computed tomography volumetry reported an FLRV of 48% with an FLRV body weight ratio of 0.55%. The second time was completed with a regulated right hepatectomy. The hospital stay was 5 days the first time and 6 days the second time, without complications. At present, the patient follows revisions in consultation without pathologic findings of interest.
In some extreme cases, surgical resection is limited by the FLRV and the risk of liver failure. Before considering liver transplant, associating liver partition and portal vein ligation for staged hepatectomy may be an effective alternative in the management of these patients.
肝腺瘤病的定义为在健康肝脏上存在超过10个腺瘤性病变。最常见的并发症是出血,发生恶性肿瘤的风险低于10%。
我们报告一例28岁患有多囊卵巢综合征的女性,口服避孕药治疗10年。超声检查显示为良性肿块,活检标本显示为腺瘤。核磁共振显示为多发性肝腺瘤病,右肝叶有一个21厘米的大结节,在第II、III、IVa、IVb、VIII - VII和VI段还有另外10个结节。进行了计算机断层扫描容积测量,观察到未来肝残余体积(FLRV)为30%,FLRV与体重比为0.34%。计划分两阶段进行手术。首先,切除第II - III、IVa和IVb段的病变,并对右门静脉进行结扎,在坎特利线使用止血带。15天后,计算机断层扫描容积测量报告FLRV为48%,FLRV与体重比为0.55%。第二次手术完成了规范的右半肝切除术。第一次住院5天,第二次住院6天,无并发症。目前,患者定期复诊,未发现有意义的病理结果。
在某些极端情况下,手术切除受FLRV和肝衰竭风险的限制。在考虑肝移植之前,联合肝分割和门静脉结扎分期肝切除术可能是治疗这些患者的有效替代方法。