Loeken M, Bikel I, Livingston D M, Brady J
Joslin Diabetes Center, Boston, Massachusetts 02215.
Cell. 1988 Dec 23;55(6):1171-7. doi: 10.1016/0092-8674(88)90261-9.
A biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors.
猴空泡病毒40小t抗原（t）在病毒感染周期中的生化作用尚不明确，该作用可以解释乳头多瘤空泡病毒中t结构的高度保守性及其在病毒转化过程中作为猴空泡病毒40大T抗原功能辅助因子的作用。在此，我们报道了该蛋白的一种细胞内生化功能——反式激活特定的依赖RNA聚合酶II和III的启动子的能力。由于t过去未能结合DNA，且不能刺激所有测试的依赖聚合酶II的启动子，它可能至少部分地通过修饰特定转录因子的活性来实现反式激活。
