Sysmex XN-10 血液分析仪检测疟疾的性能标记。
Flagging performance of Sysmex XN-10 haematology analyser for malaria detection.
机构信息
Service d'Hématologie Biologique, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France
Service de Parasitologie et Mycologie, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France.
出版信息
J Clin Pathol. 2020 Oct;73(10):676-677. doi: 10.1136/jclinpath-2019-206382. Epub 2020 Feb 7.
AIM
The aim was to assess the flagging performance of Sysmex XN-10 haematology analyser for malaria detection through the parasitic red blood cell ('pRBC') alarm.
METHODS
We retrospectively studied 584 blood samples performed on the Sysmex XN-10 analyser that were tested for malaria. Sensitivity, specificity, positive and negative predictive values, and prevalence were established for the pRBC alarm.
RESULTS
Sensitivity, specificity, and positive and negative predictive values for the pRBC flag were 7.8%, 100%, 100% and 87.7%, respectively. The prevalence of pRBC flag of 0.026% in the overall population was significantly different from the prevalence of 1.027% in the population tested for malaria.
CONCLUSIONS
Considering the excellent specificity and the low prevalence of the flag in the overall population, we suggest, in case of the presence of pRBC flag, the implementation of a rapid review of the blood smear looking for , mostly if the patient had fever and had not been tested for malaria.
目的
通过寄生虫红细胞（“pRBC”）报警评估希森美康 XN-10 血液分析仪检测疟疾的标记性能。
方法
我们回顾性研究了在 Sysmex XN-10 分析仪上进行的 584 份疟疾检测血液样本。建立了 pRBC 报警的敏感性、特异性、阳性和阴性预测值和患病率。
结果
pRBC 标记的敏感性、特异性、阳性和阴性预测值分别为 7.8%、100%、100%和 87.7%。总体人群中 pRBC 标记的患病率为 0.026%，与疟疾检测人群中的患病率 1.027%有显著差异。
结论
考虑到标记的出色特异性和总体人群中的低患病率，如果存在 pRBC 标记，我们建议快速复查血涂片寻找寄生虫，尤其是如果患者有发热且尚未进行疟疾检测。
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