Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.
Professor Emeritus, UCLA, Los Angeles, CA, USA.
J Autism Dev Disord. 2020 Aug;50(8):2874-2885. doi: 10.1007/s10803-020-04396-5.
Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.
90 名自闭症谱系障碍 (ASD) 个体的明适应 (LA) 视网膜电图 (ERG) 与 87 名对照受试者的平均年龄 (13.8 ± 4.8) 进行了比较。LA-ERG 通过随机系列的九个不同的特罗兰为基础的全视野闪光强度和 ISCEV 标准闪光在 30 cd m 的白色背景下以 2/s 的速度产生。随机效应混合模型分析显示，ASD 组在高闪光强度下的 b 波和 a 波振幅较小 (p <.001)，b 波峰时间较慢 (p <.001)。光峰模型显示，高斯 (p =.035) 和逻辑函数 (p =.014) 的峰值在组间有显著差异。通过 LA-ERG 评估的视网膜神经生理学为 ASD 中的神经发育提供了深入了解。
