Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.
Adv Exp Med Biol. 2020;1202:281-298. doi: 10.1007/978-3-030-30651-9_14.
In this chapter we describe the state of the art knowledge of the role played by myeloid cells in promoting and supporting the growth and the invasive properties of a deadly brain tumor, glioblastoma. We provide a review of the works describing the intercellular communication among glioma and associated microglia/macrophage cells (GAMs) using in vitro cellular models derived from mice, rats and human patients and in vivo animal models using syngeneic or xenogeneic experimental systems. Special emphasis will be given to 1) the timing alteration of brain microenvironment under the influence of glioma, 2) the bidirectional communication among tumor and GAMs, 3) possible approaches to interfere with or to guide these interactions, with the aim to identify molecular and cellular targets which could revert or delay the vicious cycle that favors tumor biology.
在本章中，我们描述了髓系细胞在促进和支持致命性脑肿瘤——胶质母细胞瘤生长和侵袭特性方面所起作用的最新知识。我们综述了使用源自小鼠、大鼠和人类患者的体外细胞模型以及使用同种或异种实验系统的体内动物模型来描述胶质瘤和相关小胶质细胞/巨噬细胞（GAMs）之间细胞间通讯的工作。特别强调了 1）脑微环境在胶质瘤影响下的时间变化，2）肿瘤和 GAMs 之间的双向通讯，3）可能的干预或引导这些相互作用的方法，目的是确定可以逆转或延迟有利于肿瘤生物学的恶性循环的分子和细胞靶点。
