Hospital Pharmacy Enterprises, South Eastern Norway, Oslo, Norway.
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Acta Paediatr. 2020 Nov;109(11):2394-2401. doi: 10.1111/apa.15216. Epub 2020 Feb 22.
Tablets can be manipulated in several ways to obtain a fraction as the dose-a practice frequently seen in paediatric care due to lack of suitable formulations. Splitting tablets prior to fragment dispersion in a small volume of liquid is one such method. The objective of this study was to investigate the accuracy and precision of this method.
Four different types of aspirin tablets (two dispersible, one conventional and one chewing) were split with a tablet splitter into half and quarter fragments. The fragments were dispersed in a medicine measure or an oral syringe. The amount recovered was determined by UHPLC analysis.
The largest quarter fragments ranged from 26.7% to 31.5% of the full tablet weight. Dispersing the fragment in an oral syringe, the amount recovered was greater than 90.8% of the fragment manipulated for all four tablet types, when rinsing was performed. Dispersing the fragment in a medicine measure, the amounts recovered spanned from 32.9% for the conventional tablets to 98.7% for one of the dispersible tablets.
Dispersion of half or quarter tablets directly in an oral syringe, but not a medicine measure, could give satisfactory recovery from fragments of all the investigated aspirin tablets.
可以通过多种方式操纵片剂以获得所需的剂量分数，由于缺乏合适的制剂，这种做法在儿科护理中经常见到。在将片剂分散到小体积的液体中之前，先将片剂分割成若干碎片就是其中一种方法。本研究的目的是调查这种方法的准确性和精密度。
使用片剂分割器将四种不同类型的阿司匹林片剂（两种分散片、一种普通片剂和一种咀嚼片剂）分割成半片和四分之一片碎片。将碎片分散在药杯或口腔注射器中。通过 UHPLC 分析测定回收的量。
最大的四分之一碎片的重量范围为完整片剂重量的 26.7%至 31.5%。当进行冲洗时，将碎片分散在口腔注射器中，所有四种片剂类型的碎片回收率均大于 90.8%。将碎片分散在药杯时，回收率从普通片剂的 32.9%到其中一种分散片的 98.7%不等。
直接将半片或四分之一片的片剂分散在口腔注射器中，但不在药杯中，可从所有研究的阿司匹林片剂的碎片中获得令人满意的回收率。
