Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Barrow Neurological Institute, Phoenix, Arizona, USA.
Mov Disord. 2020 May;35(5):845-850. doi: 10.1002/mds.27991. Epub 2020 Feb 8.
There are few neuropathological studies on Parkinson's disease with mild cognitive impairment (PD-MCI). Those published reveal coexisting Lewy body and Alzheimer's disease pathology. Our objective is to determine the pathology that underlies PD-MCI.
We used data from the Arizona Study of Aging and Neurodegenerative Disorders, a longitudinal clinicopathological study. Of 736 autopsied subjects with standardized movement and cognitive assessments, 25 had PD-MCI. Neuropathological findings, including Lewy body and Alzheimer's disease pathology, were compared in PD subjects with amnestic MCI (A-MCI) and nonamnestic MCI (NA-MCI).
Significant pathological heterogeneity within PD-MCI was found. This included varying Lewy body stages, Alzheimer's disease pathology, and cerebral amyloid angiopathy. There was a significant increase in the severity of Lewy body pathology (meeting The Unified Staging System for Lewy Body disorders neocortical stage) in nonamnestic MCI (7/1, 63%) when compared with amnestic MCI (3/14, 21%, P = 0.032).
Although a small study, distinct pathological changes may contribute to PD-MCI phenotype. © 2020 International Parkinson and Movement Disorder Society.
关于伴有轻度认知障碍的帕金森病（PD-MCI）的神经病理学研究较少。已发表的研究揭示了路易体和阿尔茨海默病病理学的共存。我们的目的是确定 PD-MCI 的潜在病理学。
我们使用了来自亚利桑那州衰老和神经退行性疾病纵向临床病理研究的数据。在经过标准化运动和认知评估的 736 名尸检受试者中，有 25 名患有 PD-MCI。比较了伴有遗忘型轻度认知障碍（A-MCI）和非遗忘型轻度认知障碍（NA-MCI）的 PD 患者的路易体和阿尔茨海默病病理学等神经病理学发现。
在 PD-MCI 中发现了明显的病理学异质性。这包括不同的路易体阶段、阿尔茨海默病病理学和脑淀粉样血管病。与遗忘型轻度认知障碍（3/14，21%）相比，非遗忘型轻度认知障碍（7/1，63%）中路易体病理学（符合路易体障碍统一分期系统皮质阶段）的严重程度显著增加（P=0.032）。
尽管这是一项小型研究，但不同的病理变化可能有助于 PD-MCI 的表型。 © 2020 国际帕金森病和运动障碍协会。
