de Jong T G, Hulshof J, Prokert G
Media Analytics and Computing laboratory, School of Information Science and Engineering, Xiamen University, Xiamen 361005, China.
Department of Mathematics, Faculty of Sciences VU University Amsterdam, De Boelelaan 1105, HV Amsterdam 1081, the Netherlands.
J Theor Biol. 2020 May 7;492:110189. doi: 10.1016/j.jtbi.2020.110189. Epub 2020 Feb 5.
In this paper we present a new model for single-celled, non-branching hypha tip growth. The growth mechanism of hypha cells consists of transport of cell wall building material to the cell wall and subsequent incorporation of this material in the wall as it arrives. To model the transport of cell wall building material to the cell wall we follow Bartnicki-Garcia and Gierz in assuming that the cell wall building material is transported in straight lines by an isotropic point source. To model the dynamics of the cell wall, including its growth by new material, we use the approach of Campàs and Mahadevan, which assumes that the cell wall is a thin viscous sheet sustained by a pressure difference. Furthermore, we include a novel equation which models the hardening of the cell wall as it ages. We validate the new model by comparing it to experimental data.
在本文中，我们提出了一种用于单细胞、无分支菌丝尖端生长的新模型。菌丝细胞的生长机制包括细胞壁构建材料向细胞壁的运输，以及该材料到达时在细胞壁中的后续掺入。为了模拟细胞壁构建材料向细胞壁的运输，我们遵循Bartnicki-Garcia和Gierz的假设，即细胞壁构建材料由各向同性点源沿直线运输。为了模拟细胞壁的动力学，包括其通过新材料的生长，我们采用了Campàs和Mahadevan的方法，该方法假设细胞壁是由压力差维持的薄粘性片。此外，我们纳入了一个新方程，该方程模拟了细胞壁随着老化而变硬的过程。我们通过将新模型与实验数据进行比较来验证该模型。
