Hausmann J, Deyl Z, Jelinek J, Adam M
Institute of Physiology, Czechoslovak academy of Sciences, Prague.
Connect Tissue Res. 1988;18(2):149-56. doi: 10.3109/03008208809008066.
Type V collagen was extracted and quantitated in the kidneys of unilaterally nephrectomized rats exposed to desoxycorticosteron acetate (DOCA-NaCl) treatment. A highly elevated content of collagen type V was found in these kidneys compared with controls. A higher content of collagen type V was present both in the pepsin digest of the total kidney and in the isolated glomerular basement membranes. It was previously reported that one of the factors involved in the growth of the remaining kidney in unilaterally nephrectomized DOCA-NaCl treated rats is the increase of collagen type IV, the effect being more prominent in rats nephrectomized at a younger age. The present study documents that the increase of type V collagen follows the same pattern.
在接受醋酸脱氧皮质酮（DOCA-氯化钠）治疗的单侧肾切除大鼠的肾脏中提取并定量了Ⅴ型胶原。与对照组相比，这些肾脏中Ⅴ型胶原的含量显著升高。在整个肾脏的胃蛋白酶消化物和分离出的肾小球基底膜中，Ⅴ型胶原的含量都更高。此前有报道称，在接受DOCA-氯化钠治疗的单侧肾切除大鼠中，剩余肾脏生长所涉及的因素之一是Ⅳ型胶原的增加，这种效应在较年轻就接受肾切除的大鼠中更为显著。本研究证明，Ⅴ型胶原的增加遵循相同的模式。
