Passmore J C, Whitescarver S A, Ott C E, Kotchen T A
Hypertension. 1985 May-Jun;7(3 Pt 2):I115-20. doi: 10.1161/01.hyp.7.3_pt_2.i115.
Selective dietary sodium loading (without chloride) fails to produce hypertension in the Dahl salt-sensitive rat. This study attempted to evaluate the effect of selective sodium loading on blood pressure in another NaCl-dependent model of hypertension--deoxycorticosterone acetate (DOCA)-salt hypertension. Three groups of uninephrectomized rats were studied for 32 days on one of the following regimens: (1) high NaCl diet plus DOCA, (2) high dietary sodium intake without chloride plus DOCA, and (3) high NaCl diet without DOCA. Both indirect and direct arterial pressure were higher (p less than 0.01) in the DOCA-NaCl group than in the other two groups. In the two DOCA-treated groups, net sodium and potassium balance and total carcass sodium and potassium content did not differ. In the DOCA-NaCl group, higher blood pressures were associated with a more positive chloride balance and total carcass chloride content (p less than 0.01), an expanded extracellular fluid volume (p less than 0.05), and increased renal vascular resistance (p less than 0.01). Higher renal vascular resistance in DOCA-NaCl animals suggests that chloride contributes to NaCl-induced vasoconstriction.
选择性饮食钠负荷（无氯化物）不会使Dahl盐敏感大鼠患高血压。本研究试图评估选择性钠负荷对另一种依赖氯化钠的高血压模型——醋酸脱氧皮质酮（DOCA）-盐性高血压大鼠血压的影响。将三组单肾切除大鼠按以下方案之一进行32天的研究：（1）高氯化钠饮食加DOCA，（2）高钠饮食（无氯化物）加DOCA，（3）高氯化钠饮食（无DOCA）。DOCA-氯化钠组的间接和直接动脉压均高于其他两组（p<0.01）。在两个接受DOCA治疗的组中，钠和钾的净平衡以及尸体总钠和钾含量没有差异。在DOCA-氯化钠组中，较高的血压与更正向的氯化物平衡和尸体总氯化物含量（p<0.01）、细胞外液量增加（p<0.05）以及肾血管阻力增加（p<0.01）相关。DOCA-氯化钠组动物较高的肾血管阻力表明氯化物有助于氯化钠诱导的血管收缩。
