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头皮转移癌 1 例报告

An Unusual Case of Scalp Metastasis from Breast Cancer.

机构信息

Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China; Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Department of Neurosurgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

出版信息

World Neurosurg. 2020 May;137:261-265. doi: 10.1016/j.wneu.2020.01.230. Epub 2020 Feb 6.

Abstract

BACKGROUND

The most common sites of breast cancer metastases are the bone, lung, liver, and brain. Scalp involvement in breast cancer metastasis is extraordinarily rare.

CASE DESCRIPTION

This study reports a 52-year-old woman who had a history of malignant right breast cancer and underwent a mastectomy. Positron emission tomography/computed tomography revealed a soft tissue nodule measuring 1 × 0.7 cm located subcutaneously on the top left side of the scalp. A scalp mass excision operation was performed with an extended "S"-shaped incision, and the mass was sent for pathology. Immunohistochemistry showed the following results: CK7: +; ER: 2+, 90%; GATA3: +; GCDFP-15: scattered cells+; mammaglobin: -, napsin A: -; and TTF-1: -. These results were consistent with the characteristics of primary right breast cancer, supporting scalp metastasis from breast cancer.

CONCLUSIONS

Scalp metastasis from breast cancer is an exceedingly infrequent phenomenon. Close attention should be paid to soft tissue masses in patients with a healthy appearance and in those with a history of malignant cancer. When neurosurgeons operate on the mass, the circumscription and depth of the tumor must be given further attention.

摘要

背景

乳腺癌转移最常见的部位是骨、肺、肝和脑。头皮受累在乳腺癌转移中极为罕见。

病例描述

本研究报告了一位 52 岁女性,她有右侧乳腺癌病史,并接受了乳房切除术。正电子发射断层扫描/计算机断层扫描显示头皮左上侧皮下有一个 1×0.7cm 的软组织结节。行头皮肿块切除术,采用扩展的“S”形切口,将肿块送检病理。免疫组化结果显示:CK7:+;ER:2+,90%;GATA3:+;GCDFP-15:散在细胞+;mammaglobin:-; napsin A:-;TTF-1:-。这些结果与右侧原发性乳腺癌的特征一致,支持乳腺癌头皮转移。

结论

乳腺癌头皮转移极为罕见。对于外观健康和有恶性肿瘤病史的患者,应密切注意软组织肿块。当神经外科医生对肿块进行手术时,必须进一步注意肿瘤的边界和深度。

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