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病例报告:伴有头皮转移的晚期乳腺癌:两例报告

Case report: Advanced breast cancer with scalp metastases: a report of two cases.

作者信息

Yu Jiaxuan, Yao Tianze, Zhang Min, Li Bingxin, Yao Yongqiang

机构信息

Health Management Center, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

Department of Clinical Medicine, Jinzhou Medical University, Jinzhou, China.

出版信息

Front Oncol. 2024 Oct 21;14:1382415. doi: 10.3389/fonc.2024.1382415. eCollection 2024.

Abstract

BACKGROUND

Breast cancer, identified as the most prevalent cancer worldwide, presents considerable difficulties in advanced stages, especially when involving metastatic spread. Scalp metastasis from breast cancer represents a rare and insufficiently explored occurrence. This paper seeks to illuminate this uncommon manifestation by presenting two cases of scalp metastatic breast cancer in Chinese women.

CASE REPORT

Case 1: A 45-year-old Chinese woman with a history of invasive ductal carcinoma presented with a scalp lesion indicative of recurrence. Concurrently, she was diagnosed with bone metastases and recurrence at the original site. Despite undergoing various treatments, including chemotherapy and hormonal therapy, her condition worsened, ultimately leading to her passing. Case 2: A 40-year-old Chinese woman was initially diagnosed with bilateral breast invasive mucinous carcinoma presenting with bilateral breast masses and a scalp lesion. She also had multiple bone metastases. Following chemotherapy and hormonal therapy, her disease stabilized.

CONCLUSION

These cases of scalp metastatic breast cancer underscore the complexities involved in managing advanced stages of the disease, especially with rare metastatic manifestations. They highlight the importance of comprehensive diagnostic methods, encompassing full-body skin evaluations, and draw attention to the socioeconomic challenges faced in cancer treatment. These findings point to the necessity for more targeted research on uncommon metastatic forms in breast cancer aiming to enhance patient outcomes and refine management approaches.

摘要

背景

乳腺癌被认为是全球最常见的癌症,在晚期阶段存在诸多困难,尤其是发生转移扩散时。乳腺癌头皮转移极为罕见且研究不足。本文通过介绍两例中国女性头皮转移性乳腺癌病例,旨在阐明这种不常见的表现形式。

病例报告

病例1:一名45岁有浸润性导管癌病史的中国女性,出现头皮病变提示复发。同时,她被诊断出骨转移及原发病灶复发。尽管接受了包括化疗和激素治疗在内的多种治疗,但其病情仍恶化,最终导致死亡。病例2:一名40岁的中国女性最初被诊断为双侧乳腺浸润性黏液癌,伴有双侧乳腺肿块和头皮病变。她也有多处骨转移。经过化疗和激素治疗后,病情稳定。

结论

这些头皮转移性乳腺癌病例凸显了该疾病晚期管理的复杂性,尤其是对于罕见的转移表现。它们强调了全面诊断方法的重要性,包括全身皮肤评估,并提请关注癌症治疗中面临的社会经济挑战。这些发现表明有必要针对乳腺癌不常见转移形式开展更具针对性的研究,以改善患者预后并优化管理方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e0c/11532104/6cd436004379/fonc-14-1382415-g001.jpg

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