注意缺陷多动障碍患儿脑白质微观结构不对称性改变
Altered brain white matter microstructural asymmetry in children with ADHD.
作者信息
Wu Zhao-Min, Wang Peng, Yang Li, Liu Lu, Sun Li, An Li, Cao Qing-Jiu, Chan Raymond C K, Yang Bin-Rang, Wang Yu-Feng
机构信息
Shenzhen Children's Hospital, Shenzhen, 518000, China; Peking University Sixth Hospital/Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, 100191, China; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Nijmegen, the Netherlands.
Peking University Sixth Hospital/Institute of Mental Health, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, 100191, China; Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, 100191, China.
出版信息
Psychiatry Res. 2020 Jan 28;285:112817. doi: 10.1016/j.psychres.2020.112817.
OBJECTIVES
We aimed to examine brain white matter integrity in children with ADHD.
METHODS
In a cohort of children with ADHD (n = 83) and healthy controls (n = 122), we used tract-based spatial statistics on Diffusion Tensor Imaging (DTI) data to obtain the mean fractional anisotropy (FA) in 40 bilateral regions of interest (ROIs). Lateralization Index (LI) was calculated. The difference in LI between groups and correlations between the LI of each ROI and ADHD symptom scores as well as cognitive function were examined.
RESULTS
Children with ADHD had significantly greater LI at the posterior thalamic radiation (PTR) compared with healthy controls (mean LI in ADHD = 0.0096; in Control = 0.0044, p = 0.0143), and LI of the external capsule (EC) was significantly correlated with inattention symptoms in both groups (β = -0.00059, p = 0.0181). LI of the PTR was significantly correlated with inhibitory function in healthy controls (β = -0.0008510, p = 0.0248), but not in children with ADHD.
CONCLUSION
We found increased brain white matter asymmetry (leftward) in children with ADHD compared with healthy controls at the posterior thalamic radiation. Leftward lateralization of FA values at the external capsule was negatively correlated with ADHD symptoms in both children with ADHD and healthy controls.
目的
我们旨在研究注意缺陷多动障碍（ADHD）患儿的脑白质完整性。
方法
在一组ADHD患儿（n = 83）和健康对照儿童（n = 122）中，我们对扩散张量成像（DTI）数据使用基于纤维束的空间统计学方法，以获取40个双侧感兴趣区域（ROI）的平均分数各向异性（FA）。计算偏侧化指数（LI）。检验两组之间LI的差异以及每个ROI的LI与ADHD症状评分和认知功能之间的相关性。
结果
与健康对照相比，ADHD患儿丘脑后辐射（PTR）处的LI显著更高（ADHD组的平均LI = 0.0096；对照组 = 0.0044，p = 0.0143），并且两组中外囊（EC）的LI与注意力不集中症状均显著相关（β = -0.00059，p = 0.0181）。在健康对照中，PTR的LI与抑制功能显著相关（β = -0.0008510，p = 0.0248），但在ADHD患儿中并非如此。
结论
我们发现，与健康对照相比，ADHD患儿在丘脑后辐射处脑白质不对称性增加（向左）。在ADHD患儿和健康对照中，外囊处FA值的向左偏侧化均与ADHD症状呈负相关。
Zotero 插件