Hohenberger P, Schlag P, Schwarz V, Herfarth C
Chirurgische Klinik, Universität Heidelberg.
Chirurg. 1988 Jun;59(6):410-7.
From October 1981 until July 1987 82 patients underwent hepatic resection for liver metastases of colorectal primary tumors. Operative mortality was 4.8%. This included, the median survival time was 25 months in a group of patients followed-up for at least one year postoperatively. Factors showing statistically significant influence on survival are: node-negative primary tumor, less than four metastases resected, only one liver lobe involved and decrease of CEA below 5 micrograms/ml if preoperatively elevated. Factors showing only a tendency to result in improved survival rates are the grading of the primary tumor and the percentage of liver involvement by tumor. The survival time after liver resection is similar in patients with synchronous and metachronous metastases. Thus, the time interval between the removal of the primary tumor and the detection of liver metastases seems to be gained lifetime.
从1981年10月至1987年7月,82例患者因结直肠癌原发性肿瘤肝转移接受了肝切除术。手术死亡率为4.8%。这其中,在一组术后至少随访一年的患者中,中位生存时间为25个月。对生存有统计学显著影响的因素有:原发肿瘤无淋巴结转移、切除的转移灶少于4个、仅一个肝叶受累以及术前升高的癌胚抗原(CEA)降至5微克/毫升以下。仅显示出有提高生存率趋势的因素是原发肿瘤的分级和肿瘤累及肝脏的百分比。同时性和异时性转移患者肝切除术后的生存时间相似。因此,切除原发性肿瘤与检测到肝转移之间的时间间隔似乎是额外获得的生存期。