Stephan-Otto Christian, Lombardini Federica, Núñez Christian, Senior Carl, Ochoa Susana, Usall Judith, Brébion Gildas
Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.
Psychiatry Res. 2020 Mar;285:112816. doi: 10.1016/j.psychres.2020.112816. Epub 2020 Jan 25.
Fluctuating asymmetry represents the degree to which the right and left side of the body are asymmetrical, and is a sign of developmental instability. Higher levels of fluctuating asymmetry have been observed in individuals within the schizophrenia spectrum. We aimed to explore the associations of fluctuating asymmetry with psychotic and affective symptoms in schizophrenia patients, as well as with propensity to these symptoms in non-clinical individuals. A measure of morphological fluctuating asymmetry was calculated for 39 patients with schizophrenia and 60 healthy individuals, and a range of clinical and subclinical psychiatric symptoms was assessed. Regression analyses of the fluctuating asymmetry measure were conducted within each group. In the patient cohort, fluctuating asymmetry was significantly associated with the hallucination and thought disorganisation scores. T-test comparisons revealed that the patients presenting either hallucinations or thought disorganisation were significantly more asymmetrical than were the healthy individuals, while the patients without these key symptoms were equivalent to the healthy individuals. A positive association with the anxiety score emerged in a subsample of 36 healthy participants who were rated on affective symptoms. These findings suggest that fluctuating asymmetry may be an indicator of clinical hallucinations and thought disorganisation rather than an indicator of schizophrenia disease.
波动不对称性体现了身体左右两侧不对称的程度，是发育不稳定性的一种标志。在精神分裂症谱系中的个体中观察到了更高水平的波动不对称性。我们旨在探讨波动不对称性与精神分裂症患者的精神病性症状和情感症状之间的关联，以及与非临床个体中这些症状的易感性之间的关联。对39例精神分裂症患者和60名健康个体计算了形态学波动不对称性指标，并评估了一系列临床和亚临床精神症状。在每组中对波动不对称性指标进行回归分析。在患者队列中，波动不对称性与幻觉和思维紊乱得分显著相关。t检验比较显示，出现幻觉或思维紊乱的患者比健康个体的不对称性明显更高，而没有这些关键症状的患者与健康个体相当。在36名根据情感症状进行评分的健康参与者的子样本中，发现与焦虑得分呈正相关。这些发现表明，波动不对称性可能是临床幻觉和思维紊乱的一个指标，而不是精神分裂症疾病的一个指标。
