Lübke H J, Berges W, Frieling T, Jungblut R M, Wienbeck M
Abteilung Gastroenterologie, Medizinische Klinik und Poliklinik, Universität Düsseldorf.
Dtsch Med Wochenschr. 1988 Dec 23;113(51-52):1997-2002. doi: 10.1055/s-2008-1067926.
Increasing dysphagia and weight loss between 3 and 30 kg developed in eight patients aged 27-70 years (mean age 53 years) within a period of 1.5 to 12 months. In five patients X-ray film showed the typical pattern of achalasia with dilatation of the tubular oesophagus and a smooth taper of the terminal part. Although in all patients the cardia became patent only after the endoscope had been advanced by pushing it forward to overcome stenosis or after bougienage, and although the malignoma had always been included in differential diagnostic considerations, a malignoma was identified only three times in 30 histological examinations. Oesophageal manometry demonstrated findings characteristic of achalasia in five patients, in three patients the examination could be performed only incompletely. In six patients computed tomography revealed pathological hypertrophy of the cardiac wall. Intraoperatively all cardiac tumours were in an advanced stage.
8名年龄在27至70岁(平均年龄53岁)的患者在1.5至12个月内出现吞咽困难加重和体重减轻3至30千克。5名患者的X线片显示出贲门失弛缓症的典型表现,即管状食管扩张,末端呈光滑锥形。尽管所有患者只有在内镜通过向前推以克服狭窄或扩张术后贲门才通畅,并且尽管始终将恶性肿瘤纳入鉴别诊断考虑范围,但在30次组织学检查中仅3次确诊为恶性肿瘤。食管测压显示5名患者有贲门失弛缓症的特征性表现,3名患者的检查仅能不完全进行。6名患者的计算机断层扫描显示贲门壁病理性肥厚。术中发现所有贲门肿瘤均处于晚期。