Department of Sense Organs, University Sapienza of Rome, Rome, Italy.
Semin Ophthalmol. 2020 Jan 2;35(1):50-55. doi: 10.1080/08820538.2020.1723651. Epub 2020 Feb 8.
: To describe the clinical characteristics and visual prognosis of ocular involvement in syphilis.: A retrospective cohort study.: We studied the charts of 24 patients who visited our Ophthalmological Centre in Rome, Italy. All patients with serological evidence of syphilitic infection were included.: Ocular involvement was the first manifestation of syphilitic disease in 96% and Human Immunodeficiency Virus (HIV) seropositivity was found in 29% of the cases. The most frequent ocular manifestation was posterior uveitis. Vitreous involvement was frequent. Patients with papillitis at onset showed better visual outcome with antisyphilitic treatment. Posterior uveitis at onset and HIV seropositivity were negative prognostic factors for visual outcome. HIV-positive patients showed more severe and frequent bilateral course of ocular involvement in syphilis.: The ophthalmologist should suspect syphilis in patien ts with uveitis or optic neuropathy associated with high-risk sexual behaviour and/or HIV, or in patients with posterior placoid chorioretinitis, necrotising retinitis, or interstitial keratitis.
: 描述梅毒眼部受累的临床特征和视觉预后。: 一项回顾性队列研究。: 我们研究了 24 名在意大利罗马眼科中心就诊的患者的图表。所有血清学证据表明患有梅毒感染的患者均被纳入研究。: 眼部受累是梅毒疾病的首发表现，占 96%，29%的病例人类免疫缺陷病毒 (HIV) 血清阳性。最常见的眼部表现是后葡萄膜炎。玻璃体受累很常见。发病时出现视乳头炎的患者经抗梅毒治疗后视力预后较好。发病时出现后葡萄膜炎和 HIV 血清阳性是视觉预后的负性预测因素。HIV 阳性患者的梅毒眼部受累更严重且更频繁地表现为双侧性。: 眼科医生应怀疑患有葡萄膜炎或视神经病变的患者患有梅毒，这些患者与高危性行为和/或 HIV 有关，或患有后发性盘状脉络膜视网膜炎、坏死性视网膜炎或间质性角膜炎。
