中国北方梅毒葡萄膜炎的特征
Characteristics of syphilitic uveitis in northern China.
作者信息
Zhang Xiaomin, Du Qian, Ma Feifei, Lu Yinglong, Wang Meiyan, Li Xiaorong
机构信息
Eye Institute & School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, 251 Fukang Road, Nankai District, Tianjin, 300384, China.
Department of Uveitis & Ocular Immunology, Eye Institute & School of Optometry and Ophthalmology, Tianjin Medical University Eye Hospital, 251 Fukang Road, Nankai District, Tianjin, 300384, China.
出版信息
BMC Ophthalmol. 2017 Jun 19;17(1):95. doi: 10.1186/s12886-017-0491-6.
BACKGROUND
To describe the characteristics of patients with syphilitic uveitis in northern China.
METHODS
A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed.
RESULTS
Twenty-one patients (33 eyes) were diagnosed as syphilitic uveitis. Posterior segment involvement was found in 32 eyes (97.0%). Vitreous haze, neuroretinitis, and posterior placoid chorioretinitis were mainly found in patients with a relatively short duration of the disease, while diffuse chorioretinitis, pseudoretinitis pigmentosa, cystoid macular edema, and epiretinal membrane were found in patients with relatively long duration of ocular involvement. A low best-corrected visual acuity (P = 0.022) and a delay of syphilis treatment (P < 0.001) were associated with a significantly worse visual outcome.
CONCLUSIONS
Syphilitic uveitis should be included in the differential diagnosis of any form of posterior ocular inflammation. The pattern of ocular involvement may change with the disease progression.
背景
描述中国北方梅毒葡萄膜炎患者的特征。
方法
回顾性分析2011年至2016年在中国北方一家三级中心诊断为梅毒葡萄膜炎的21例患者（33只眼）的病例系列。
结果
21例患者（33只眼）被诊断为梅毒葡萄膜炎。32只眼（97.0%）有后段受累。玻璃体混浊、神经视网膜炎症和后极部扁平状脉络膜视网膜炎症主要见于病程相对较短的患者，而弥漫性脉络膜视网膜炎症、假性视网膜色素变性、黄斑囊样水肿和视网膜前膜见于眼部受累病程相对较长的患者。最佳矫正视力低（P = 0.022）和梅毒治疗延迟（P < 0.001）与明显更差的视力预后相关。
结论
梅毒葡萄膜炎应纳入任何形式的后部眼部炎症的鉴别诊断。眼部受累模式可能随疾病进展而改变。
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