Irion G L, Vasthare U S, Tuma R F
Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Exp Gerontol. 1988;23(3):183-8. doi: 10.1016/0531-5565(88)90005-8.
In a previous investigation (Irion et al., 1987), a significant age-related decline in skeletal muscle blood flow during intermittent tetanic contractions was observed in male Fischer 344 rats. This decline in the hyperemic response to muscle contraction was accompanied by an increased fatigability of skeletal muscle of senescent male rats. In the present investigation, anesthetized female adult and senescent Fischer 344 rats were instrumented for stimulation of the plantar flexor muscles in situ, and blood flow measurement by the tracer microsphere technique. After determination of optimum length and maximum tetanic force, muscles were stimulated to contract at the rate of 120 tetani/min. No significant differences could be observed between adult and senescent females in skeletal muscle fatigability or blood flow. The only significant differences observed between senescent and younger females were a decrease in splenic blood flow and an increase in body weight. In contrast to male rats of the same age, no impairment of skeletal muscle blood flow or change in fatigability could be detected in senescent female rats.
在之前的一项研究（伊里昂等人，1987年）中，在雄性费希尔344大鼠间歇性强直收缩期间，观察到骨骼肌血流量出现显著的与年龄相关的下降。对肌肉收缩的充血反应的这种下降伴随着衰老雄性大鼠骨骼肌疲劳性的增加。在本研究中，对成年和衰老的雌性费希尔344大鼠进行麻醉，通过示踪微球技术原位刺激足底屈肌并测量血流量。在确定最佳长度和最大强直力后，以120次强直/分钟的频率刺激肌肉收缩。成年和衰老雌性大鼠在骨骼肌疲劳性或血流量方面未观察到显著差异。衰老和年轻雌性大鼠之间唯一观察到的显著差异是脾血流量减少和体重增加。与同龄雄性大鼠不同，在衰老雌性大鼠中未检测到骨骼肌血流量受损或疲劳性变化。
