Irion G L, Vasthare U S, Tuma R F
Department of Physiology, Temple University School of Medicine.
J Gerontol. 1987 Nov;42(6):660-5. doi: 10.1093/geronj/42.6.660.
Anesthetized adult and senescent male Fischer 344 rats were instrumented for stimulation of in situ plantar flexor muscles and blood flow measurement by the tracer microsphere technique. After determination of optimum length and maximum tetanic force, muscles were stimulated to contract at the rate of 120 tetani/min. Senescent rats displayed significantly lower muscle blood flow and greater muscle fatigue than younger rats. Infusion of a nonspecific vasodilator in resting anesthetized rats also revealed a significantly lower potential to increase muscle blood flow in the senescent rats. Lower muscle blood flow of senescent rats during muscle contractions might be responsible, at least in part, for decreased performance of muscles of senescent male rats.
对成年和老年雄性Fischer 344大鼠进行麻醉，通过示踪微球技术对其原位足底屈肌进行刺激并测量血流。在确定最佳长度和最大强直力后，以120次强直收缩/分钟的速率刺激肌肉收缩。与年轻大鼠相比，老年大鼠的肌肉血流量显著降低，肌肉疲劳程度更高。对处于麻醉状态的静息大鼠输注非特异性血管扩张剂，结果也显示老年大鼠增加肌肉血流量的潜力显著降低。老年大鼠在肌肉收缩过程中较低的肌肉血流量可能至少部分导致了老年雄性大鼠肌肉性能的下降。
