自动化获取精确定义的离子寡糖。
Automated access to well-defined ionic oligosaccharides.
机构信息
Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.
Department of Theory, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.
出版信息
Org Biomol Chem. 2020 Feb 19;18(7):1349-1353. doi: 10.1039/d0ob00137f.
Ionic polysaccharides are part of many biological events, but lack structural characterisation due to challenging purifications and complex synthesis. Four monosaccharides bearing modifications not found in nature are used for the automated synthesis of a collection of ionic oligosaccharides. Structural analysis reveals how the charge pattern affects glycan conformation.
离子多糖是许多生物事件的一部分，但由于提纯困难和合成复杂，缺乏结构特征。四种在自然界中不存在修饰的单糖被用于自动合成一系列离子低聚糖。结构分析揭示了电荷模式如何影响聚糖构象。
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