Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, P. R. China.
Key Laboratory of Chemical Biology and Traditional Chinese Medicine (Hunan Normal University), Ministry of Education, Changsha 410082, P. R. China.
Chem Commun (Camb). 2020 Mar 5;56(19):2901-2904. doi: 10.1039/c9cc09503a.
The enzymatic-assisted signal amplification of DNA sensors is rarely applied in living cells due to the difficulties in protein delivery. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.
由于蛋白质递送的困难，酶辅助的 DNA 传感器信号放大在活细胞中很少应用。在本研究中，我们提出了一种基于生物矿化的 DNA 纳米探针，用于输送核酸酶和 DNA 传感器，以在活细胞中进行酶辅助的 microRNA 成像。
