Paul Scherrer Institut (PSI), Center for Proton Therapy, 5232, Villigen PSI, Switzerland.
Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Med Phys. 2020 Jun;47(5):2237-2241. doi: 10.1002/mp.14087. Epub 2020 Mar 10.
Ocular proton therapy is an effective therapeutic option for patients affected with uveal melanomas. An optical eye-tracking system (ETS) aiming at noninvasive motion monitoring was developed and tested in a clinical scenario.
The ETS estimates eye position and orientation at 25 frames per second using the three-dimensional position of pupil and cornea curvature centers identified, in the treatment room, through stereoscopic optical imaging and infrared eye illumination. Its capabilities for automatic detection of eye motion were retrospectively evaluated on 60 treatment fractions. Then, the ETS performance was benchmarked against the clinical standard based on visual control and manual beam interruption.
Eye-tracking system detected eye position successfully in 97% of all available frames. Eye-tracking system-based eye monitoring during therapy guarantees quicker response to involuntary eye motions than manual beam interruptions and avoids unnecessary beam interruptions.
Eye-tracking system shows promise for on-line monitoring of eye motion. Its introduction in the clinical workflow will guarantee a swifter treatment course for the patient and the clinical personnel.
眼部质子治疗是治疗葡萄膜黑色素瘤患者的有效治疗选择。本研究开发了一种旨在进行非侵入性运动监测的光学眼跟踪系统（ETS），并在临床环境中进行了测试。
该 ETS 使用立体光学成像和红外眼部照明在治疗室中识别瞳孔和角膜曲率中心的三维位置，以每秒 25 帧的速度估计眼位置和方向。通过回顾性分析 60 个治疗分数来评估其自动检测眼部运动的能力。然后，将 ETS 性能与基于视觉控制和手动光束中断的临床标准进行基准比较。
眼跟踪系统在所有可用帧中成功检测到眼位置的比例为 97%。与手动光束中断相比，治疗过程中基于眼跟踪系统的眼部监测可更快地响应非自愿性眼部运动，并避免不必要的光束中断。
眼跟踪系统有望用于在线监测眼部运动。将其引入临床工作流程将保证患者和临床人员更快地完成治疗过程。
