Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry (Tianjin Normal University), Ministry of Education, Tianjin Key Laboratory of Structure and Performance for Functional Molecule, College of Chemistry, Tianjin Normal University, 393 Binshui West Road, Tianjin 300387, PR China.
Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, PR China.
Inorg Chem. 2020 Mar 2;59(5):2910-2922. doi: 10.1021/acs.inorgchem.9b03272. Epub 2020 Feb 10.
Through powerful solvothermal and facile ultrasonic synthetic strategies, two unique cluster-based lanthanide Lu and Y nanoporous metal organic frameworks (MOFs) have been successfully prepared, namely, {[Lu(L)]·2DMF·HO} () and [Y(L)(DMF)] () (HL = terphenyl-3,4'',5-tricarboxylic acid). In addition, both the morphologies and nanosizes of and materials also have been deliberately tuned by adjustable ultrasonic conditions including irradiation time (40, 60, and 80 min) and power (70 w, 100 w). Currently, it is noted that the abuse of antibiotics such as ornidazole and ronidazole leads to great damage to human health, and therefore the development of highly effective and facile detection methods for ornidazole and ronidazole is quite important. Herein, to improve the fluorescent sensing sensitivity of antibiotics, Eu and Tb have been introduced into (under a solvothermal preparation method) to fabricate a dual-emission hybrid material through a postsynthesis strategy, which can be successfully applied as a self-calibrated ratiometric fluorescent sensor for ornidazole and ronidazole with high selectivity and sensitivity (the value for ornidazole is 1.0854 × 10 [M], and the value for ronidazole is 1.0595 × 10 [M]) and low detection limit values (2.85 nM for ornidazole and 26.7 nM for ronidazole). On the other hand, amoeba liver abscess (ALA) will easily lead to irregular fever, night sweats, and other tortured symptoms; C-reactive protein autoantibody (CRP Ab) is the important biomarker for the detection of ALA. Given this, (under the solvothermal preparation method) also has been successfully designed to combine FAM-labeled NH-ssDNA to construct the scarcely reported excellent hybrid FAM-labeled NH-ssDNA/ sensing platform for the highly effective discrimination of CRP Ab with excellent sensitivity and selectivity in real samples such as human serum solution.
通过强大的溶剂热和简便的超声合成策略，成功制备了两种独特的基于簇的镥和钇纳米多孔金属有机骨架（MOFs），即{[Lu（L）]·2DMF·HO}（）和[Y（L）（DMF）]（）（HL = 三联苯-3,4'',5-三羧酸）。此外，和材料的形态和纳米尺寸也通过可调节的超声条件（包括照射时间（40、60 和 80 分钟）和功率（70 w、100 w））进行了有意调整。目前，值得注意的是，奥硝唑和罗硝唑等抗生素的滥用对人类健康造成了极大的损害，因此开发高效简便的奥硝唑和罗硝唑检测方法非常重要。在这里，为了提高抗生素的荧光传感灵敏度，通过后合成策略将 Eu 和 Tb 引入（在溶剂热制备方法下）制备了双发射杂化材料，该杂化材料可以成功用作奥硝唑和罗硝唑的高选择性和高灵敏度（奥硝唑的 值为 1.0854×10 [M]，罗硝唑的 值为 1.0595×10 [M]）和低检测限值（奥硝唑为 2.85 nM，罗硝唑为 26.7 nM）的自校准比率荧光传感器。另一方面，肝脓肿（ALA）容易导致不规则发热、盗汗等折磨人的症状；C-反应蛋白自身抗体（CRP Ab）是检测 ALA 的重要生物标志物。鉴于此，（在溶剂热制备方法下）也成功地设计为结合 FAM 标记的 NH-ssDNA 构建了鲜有报道的出色杂交 FAM 标记的 NH-ssDNA/，用于在人血清溶液等实际样品中对 CRP Ab 进行高效区分，具有出色的灵敏度和选择性。
