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[自体重建手术与肠道康复在短肠综合征治疗中的应用]

[Autologous reconstructive surgery and intestinal rehabilitation in the management of short bowel syndrome].

作者信息

Urbán Dániel, Kőnig Róbert, Cserni Tamás

机构信息

Sebészeti és Mellkassebészeti Osztály,Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház és RendelőintézetSzolnok.

Sebészeti Műtéttani Intézet,Szegedi Tudományegyetem, Általános Orvostudományi KarSzeged.

出版信息

Orv Hetil. 2020 Feb;161(7):243-251. doi: 10.1556/650.2020.31655.

DOI:10.1556/650.2020.31655
PMID:32037869
Abstract

Based on the latest definition, short bowel syndrome is defined as intestinal failure due to the loss of significant small bowel length or function, when the homeostasis and growth can only be maintained with intravenous supplementation of fluid, electrolytes and macronutrients. The natural adaptation of the short bowel can only compensate for the loss up to a certain level. According to this, we differentiate (1) acute, (2) prolonged and (3) chronic types of intestinal failure/short bowel syndrome. The most common causes are necrotising enterocolits, intestinal malrotation and volvulus, gastroschisis and ileal atresia. The management of type 3 short bowel syndrome has evolved significantly during the last decades, due to the multidisciplinary approach, hence the survival and quality of life of the patients have improved and transplantation is rarely necessary. Our aim was to review the most important considerations of intestinal rehabilitation, like management of increased gastrin secretion, high output stoma, decreased transit time, central venous lines, enteral and parenteral nutrition and the enhancement of the natural adaptation. We reviewed the former and the latest options of the autologous intestinal reconstructive surgery (AIRS) like the reversed segment, small bowel interposition, ileocaecal valve replacement, bowel lengthening and tailoring (LILT, STEP and SILT), controlled bowel expansion and the latest results with distraction enterogenesis and tissue engineering. Orv Hetil. 2020; 161(7): 243-251.

摘要

根据最新定义,短肠综合征被定义为由于小肠长度或功能大量丧失导致的肠衰竭,此时只有通过静脉补充液体、电解质和大量营养素才能维持体内平衡和生长。短肠的自然适应性只能在一定程度上弥补损失。据此,我们将肠衰竭/短肠综合征分为(1)急性、(2)迁延性和(3)慢性三种类型。最常见的病因是坏死性小肠结肠炎、肠旋转不良和肠扭转、腹裂和回肠闭锁。在过去几十年中,由于多学科方法,3型短肠综合征的治疗有了显著进展,因此患者的生存率和生活质量得到了改善,很少需要进行移植。我们的目的是回顾肠道康复的最重要考虑因素,如胃泌素分泌增加的管理、高输出造口、转运时间缩短、中心静脉置管、肠内和肠外营养以及自然适应性的增强。我们回顾了自体肠道重建手术(AIRS)的既往和最新选择,如逆行肠段、小肠间置、回盲瓣置换、肠延长和裁剪(LILT、STEP和SILT)、控制性肠扩张以及牵张肠再生和组织工程的最新结果。《匈牙利医学周报》。2020年;161(7):243 - 251。

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