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黄斑部鱼雷样病变:病例系列——对基本病理的深入了解。

Torpedo maculopathy: A case series - insights into basic pathology.

机构信息

Maidstone Hospital, Kent, UK.

Guy's and St Thomas' NHS Foundation Trust, London, UK.

出版信息

Eur J Ophthalmol. 2021 May;31(3):NP35-NP39. doi: 10.1177/1120672120905313. Epub 2020 Feb 9.

Abstract

Torpedo maculopathy is a benign retinal disorder whose pathophysiological origins are currently poorly understood. A number of theories have been postulated, with stable developmental anomalies of the retinal pigment epithelium taking the forefront. Four clinical cases are outlined of patients with macular torpedo lesions, with differing clinical presentation. In all four cases, this reveals very thin retinal pigment epithelium and outer retina associated with the lesion. In a single case, the oldest patient of the group, there is the additional finding of subretinal and intraretinal fluid accumulation. The contrast between this case and the other cases suggests that while initially this benign pathology might start with structurally normal retina with no fluid accumulation, dysgenetic changes in the retinal pigment epithelium might lead to secondary accumulation of fluid over time. Whether indeed this disorder might be progressive in nature, or whether in fact it is a static, non-progressive developmental abnormality as formerly thought, requires further elucidation.

摘要

黄斑鱼雷病变是一种良性的视网膜疾病,其病理生理起源目前还了解甚少。目前已经提出了许多理论,其中视网膜色素上皮的稳定发育异常处于领先地位。本文概述了 4 例具有不同临床表现的黄斑鱼雷病变患者的临床病例。在所有 4 例中,均发现病变处的视网膜色素上皮和外视网膜非常薄。在该组中最年长的患者中,还有一个附加发现,即视网膜下和视网膜内液体积聚。这种情况与其他病例之间的差异表明,虽然最初这种良性病变可能始于没有液体积聚的结构正常的视网膜,但视网膜色素上皮的发育异常可能会导致随着时间的推移液体积聚的继发性增加。这种疾病是否确实具有进展性,或者实际上它是否像以前认为的那样是一种静态的、非进行性的发育异常,需要进一步阐明。

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