Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, China.
Front Neural Circuits. 2020 Jan 23;13:80. doi: 10.3389/fncir.2019.00080. eCollection 2019.
Methamphetamine (meth) can greatly damage the prefrontal cortex of the brain and trigger dysfunction of the cognitive control loop, which triggers not only drug dependence but also emotional disorders. The imbalance between the cognitive and emotional systems will lead to crossmodal emotional deficits. Until now, the negative impact of meth dependence on crossmodal emotional processing has not received attention. Therefore, the present study firstly examined the differences in crossmodal emotional processing between healthy controls and meth dependents (MADs) and then investigated the role of visual- or auditory-leading cues in the promotion of crossmodal emotional processing. Experiment 1 found that MADs made a visual-auditory integration disorder for fearful emotion, which may be related to the defects in information transmission between the auditory and auditory cortex. Experiment 2 found that MADs had a crossmodal disorder pertaining to fear under visual-leading cues, but the fearful sound improved the detection of facial emotions for MADs. Experiment 3 reconfirmed that, for MADs, A-leading cues could induce crossmodal integration immediately more easily than V-leading ones. These findings provided sufficient quantitative indicators and evidences that meth dependence was associated with crossmodal integration disorders, which in turn was associated with auditory-leading cues that enhanced the recognition ability of MADs for complex emotions (all results are available at: https://osf.io/x6rv5/). These results provided a better understanding for individuals using drugs in order to enhance the cognition for the complex crossmodal emotional integration.
甲基苯丙胺（冰毒）会严重损害大脑的前额叶皮层，并引发认知控制回路的功能障碍，不仅会导致药物依赖，还会引发情绪障碍。认知和情绪系统之间的失衡会导致跨模态情绪缺陷。到目前为止，冰毒依赖对跨模态情绪处理的负面影响尚未受到关注。因此，本研究首先考察了健康对照组和冰毒依赖者（MADs）之间跨模态情绪处理的差异，然后研究了视觉或听觉主导线索在促进跨模态情绪处理中的作用。实验 1 发现 MADs 对恐惧情绪的视听整合出现障碍，这可能与听觉和听觉皮层之间的信息传递缺陷有关。实验 2 发现 MADs 在视觉主导线索下对恐惧存在跨模态障碍，但恐惧声音改善了 MADs 对面部情绪的检测。实验 3 再次证实，对于 MADs，A 主导线索比 V 主导线索更能立即更容易地诱导跨模态整合。这些发现提供了充分的定量指标和证据，表明冰毒依赖与跨模态整合障碍有关，而听觉主导线索则增强了 MADs 对复杂情绪的识别能力（所有结果均可在：https://osf.io/x6rv5/ 获取）。这些结果为理解个体使用药物来增强对复杂跨模态情绪整合的认知提供了更好的依据。
