Beauchet Olivier, Montembeault Maxime, Allali Gilles
Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada.
Dr. Joseph Kaufmann Chair in Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Front Aging Neurosci. 2020 Jan 21;11:364. doi: 10.3389/fnagi.2019.00364. eCollection 2019.
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between the TUG delta time and brain gray matter (GM) volumes in CHI and individuals with MCI. A total of 326 participants, 156 CHI and 170 MCI, with TUG delta time and a brain T1-weighted magnetic resonance imaging (MRI) were selected in this cross-sectional study. Individuals with MCI were older and had greater (i.e., worst performance) performed TUG and TUG delta time compared to CHI. The GM volume association with TUG delta time was examined in CHI and MCI assuming that increased TUG delta time would be associated with locally decreased GM volumes. No significant association was found in CHI, whereas TUG delta time was negatively associated with the GM volume of the right medial temporal lobe in individuals with MCI.
与认知健康个体（CHI）相比，轻度认知障碍（MCI）患者的步态表现更差。想象与实际执行的计时起立行走测试（TUG）之间的差异，即TUG时间差，是MCI患者脑步态控制受损的一个标志。本研究旨在探讨CHI和MCI患者中TUG时间差与脑灰质（GM）体积之间的关联。在这项横断面研究中，共选取了326名参与者，其中156名CHI和170名MCI，他们均有TUG时间差和脑部T1加权磁共振成像（MRI）数据。与CHI相比，MCI患者年龄更大，执行TUG和TUG时间差更大（即表现更差）。假设TUG时间差增加与局部GM体积减少相关，对CHI和MCI患者中GM体积与TUG时间差的关联进行了研究。在CHI中未发现显著关联，而在MCI患者中，TUG时间差与右侧内侧颞叶的GM体积呈负相关。
