Jahani Reza, Khaledyan Dariush, Jahani Ali, Jamshidi Elham, Kamalinejad Mohammad, Khoramjouy Mona, Faizi Mehrdad
Student Research Committee, Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Faculty of Natural Environment and Biodiversity, College of Environment, Karaj, I.R. Iran.
Res Pharm Sci. 2019 Dec 11;14(6):544-553. doi: 10.4103/1735-5362.272563. eCollection 2019 Dec.
Several studies have supported the preventive and therapeutic values of phenolic compounds including chlorogenic acid, syringic acid, vanillic acid, ferulic acid, caffeic acid, luteolin, rutin, catechin, kaempferol, and quercetin in mental disorders. Since these secondary metabolites are reported as the phenolic compounds of and , the main aim of this study was the evaluation and comparison of the phenolic contents, flavonoids, and antidepressant-like activity of with . Antidepressant-like activity of the extracts was evaluated in the forced swimming test (FST) and the tail suspension test (TST). Moreover, the open field test was conducted to evaluate the general locomotor activity of mice following treatment with the extracts. Since phenolic compounds and flavonoids play main roles in pharmacological effects, the phenolic and flavonoid contents of the extracts were measured. Though significant difference between the phenolic contents of the extracts was not observed, but exhibited higher flavonoid contents. Animal treatment with extracts decreased the immobility times in both FST and TST compared to the vehicle group without any significant effect on the locomotor activity of animals. Also, at 400 mg/kg showed higher potency in both tests compared to . Our results provided promising evidence on the antidepressant-like activity of both extracts which could be related to flavonoids as the main components of the extracts, but more studies need to be conducted to specify the main compounds and the mechanisms involved in the observed effects.
多项研究证实了酚类化合物（包括绿原酸、丁香酸、香草酸、阿魏酸、咖啡酸、木犀草素、芦丁、儿茶素、山柰酚和槲皮素）在精神障碍方面的预防和治疗价值。由于这些次生代谢产物被报道为[具体物质1]和[具体物质2]的酚类化合物，本研究的主要目的是评估和比较[提取物1]与[提取物2]的酚类含量、黄酮类化合物含量及抗抑郁样活性。通过强迫游泳试验（FST）和悬尾试验（TST）评估提取物的抗抑郁样活性。此外，进行旷场试验以评估小鼠经提取物处理后的一般运动活性。由于酚类化合物和黄酮类化合物在药理作用中起主要作用，因此测定了提取物中的酚类和黄酮类含量。虽然未观察到提取物酚类含量之间的显著差异，但[提取物2]表现出更高的黄酮类含量。与溶剂对照组相比，用提取物处理动物可减少FST和TST中的不动时间，且对动物的运动活性无显著影响。此外，在两种试验中，400mg/kg的[提取物2]比[提取物1]表现出更高的效力。我们的结果为两种提取物的抗抑郁样活性提供了有前景的证据，这可能与提取物中的主要成分黄酮类化合物有关，但需要进行更多研究以确定主要化合物及所观察到的效应涉及的机制。
