Kwack Seung Jun, Lee Byung Mu
16Department of Toxicological Research, National Institute of Toxicological Research, Seoul, 122-704 Korea.
26Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun-dong 300, Changan-ku, Suwon, Gyeonggi-do, 440-746 Korea.
Toxicol Res. 2009 Jun;25(2):101-106. doi: 10.5487/TR.2009.25.2.101. Epub 2009 Jun 1.
This study was conducted to investigate the 2 week-oral toxicity of in Sprague-Dawley rats. was daily administered to male and female rats for 2 weeks with different dose levels (0, 0.008, 0.04, 0.2, 1 and 5 g/kg). There were no clinical signs compared with control group, but a slight increase of white blood cell (WBC) was observed in the males rats receiving all dose levels of . In biohematological analysis, the levels of glucose and cholesterol in the blood were decreased slightly in the males and females rats at doses of 0.008 or 1 g/kg. At the all dose groups, there were no significant changes in the body weights, but autopsy findings of all organs showed reduced weights in the thymus of males in the high dose groups of 1 g/kg and 5 g/kg. These results indicate that does not induce any significant toxic effect on Sprague-Dawley rats treated for 2 weeks, but the reduced weights of thymus in males may require a further long-term investigation.
本研究旨在调查[具体物质未给出]对斯普拉格-道利大鼠的两周经口毒性。以不同剂量水平（0、0.008、0.04、0.2、1和5克/千克）对雄性和雌性大鼠每日给药[具体物质未给出]，持续两周。与对照组相比，未观察到临床症状，但在接受所有剂量水平[具体物质未给出]的雄性大鼠中观察到白细胞（WBC）略有增加。在血液学分析中，剂量为0.008或1克/千克时，雄性和雌性大鼠血液中的葡萄糖和胆固醇水平略有下降。在所有剂量组中，体重没有显著变化，但在1克/千克和5克/千克高剂量组的雄性大鼠中，所有器官的尸检结果显示胸腺重量减轻。这些结果表明，[具体物质未给出]对接受两周治疗的斯普拉格-道利大鼠未诱导任何显著的毒性作用，但雄性大鼠胸腺重量减轻可能需要进一步的长期研究。
