Zhang Xiaofeng, Hu Qiongbo, Weng Qunfang
College of Agriculture, South China Agricultural University Guangzhou 510642 China
RSC Adv. 2018 Dec 21;9(1):172-184. doi: 10.1039/c8ra09039d. eCollection 2018 Dec 19.
Both and are important entomopathogenic fungi used in health foods and traditional herbal medicines in East Asia. However, the safety concerns for both fungal species have been attracting significant attention. Thus, surveying their secondary metabolites (SMs) will be beneficial to improving the safety of their fungal products. In the case of , its SMs mainly include nucleosides, amino acids, beauvericins, myriocin, and oosporein. In contrast, trichothecene derivatives, isariotins, cyclopenta benzopyrans and PKs, are found in the case of . Among them, beauvericins, myriocin, oosporein and many trichothecene derivatives are toxic compounds. The toxicity and side effects of the fungal products may be related to these SMs. Thus, to ensure the safety of fungal products, the residues standards of SMs need to be reported. Furthermore, methods for the detection of their SMs and biological identification of their strains must be considered. This review gives new insight into the secondary metabolites of medical and edible fungi.
两者都是东亚用于保健食品和传统草药的重要昆虫病原真菌。然而，这两种真菌物种的安全性问题一直备受关注。因此，研究它们的次生代谢产物（SMs）将有助于提高其真菌产品的安全性。就而言，其SMs主要包括核苷、氨基酸、白僵菌素、嗜皮菌素和卵孢霉素。相比之下，在的情况下发现了单端孢霉烯衍生物、异座菌素、环戊苯并吡喃和PKs。其中，白僵菌素、嗜皮菌素、卵孢霉素和许多单端孢霉烯衍生物都是有毒化合物。真菌产品的毒性和副作用可能与这些SMs有关。因此，为确保真菌产品的安全性，需要报告SMs的残留标准。此外，还必须考虑检测其SMs的方法及其菌株的生物学鉴定。本综述为药用和食用真菌的次生代谢产物提供了新的见解。
